Evidence map›Paper›PMID 26033955›Full record

ArticleJournal of tissue engineering and regenerative medicine2017

Decorin mimic promotes endothelial cell health in endothelial monolayers and endothelial-smooth muscle co-cultures.

Rebecca A Scott, Aneesh K Ramaswamy, Kinam Park, Alyssa Panitch

Open access · greenAbstract read
In one paragraph

Article in Journal of tissue engineering and regenerative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Biomimetic strategies for the deputization of proteoglycan functions.Frontiers in cell and developmental biology · 2024
    Review
  2. Review
  3. A Possible Role for Arylsulfatase G in Dermatan Sulfate Metabolism.International journal of molecular sciences · 2020
    Article
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rebecca A ScottWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Aneesh K RamaswamyWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Kinam ParkWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Alyssa PanitchWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Purdue University West Lafayette · US

Funding

Improved Therapeutics for Drug Eluting StentsR01HL106792 · NHLBI · PURDUE UNIVERSITY · PI PANITCH, ALYSSA · 2011 to 2014
$1.5M
NHLBI NIH HHS R01 HL106792
6 · The paper itself

Abstract

Non-specific cytotoxins, including paclitaxel and sirolimus analogues, currently utilized as anti-restenotic therapeutics, affect not only smooth muscle cells (SMCs) but also neighbouring vascular endothelial cells (ECs). These drugs inhibit the formation of an intact endothelium following vessel injury, thus emphasizing the critical need for new candidate therapeutics. Utilizing our in vitro models, including EC monolayers and both hyperplastic and quiescent EC-SMC co-cultures, we investigated the ability of DS-SILY

Indexed as

DecorinBiomimetic MaterialsCell SurvivalCoculture TechniquesCytokinesEndothelial CellsHumansMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Muscle, Smooth, VascularMyocytes, Smooth MuscleCytokinesDCN protein, humanDecorinMAPK1 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3co-culturedecorindermatan sulphateendothelial cellsproteoglycanvascular smooth muscle cells

Identifiers

PMID26033955
PMCPMC6368354
OpenAlexW2124621404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.