ArticleBMJ open2015
A cross-sectional study on upright heart rate and BP changing characteristics: basic data for establishing diagnosis of postural orthostatic tachycardia syndrome and orthostatic hypertension.
Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Guidelines for the diagnosis and treatment of neurally mediated syncope in children and adolescents (revised 2024).World journal of pediatrics : WJP · 2024Guideline
- Diagnostic strategies, test accuracy, and misdiagnosis of POTS: a narrative review of diagnostic criteria, tests, and diagnostic delay.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Review
- The Changes of T-Wave Amplitude and Tp-Te Interval in the Supine and Standing Electrocardiograms of Pediatric Postural Orthostatic Tachycardia Syndrome and Their Predictive Value for the Intervention Effect of Metoprolol.Journal of clinical medicine · 2026Article
- Cardiovascular Response to Active Standing Test in Children with Overweight and Obesity.Turkish archives of pediatrics · 2025Article
- Orthostatic Intolerance in Children With Long COVID Utilizing a 10-Minute Passive Standing Test.Clinical pediatrics · 2025Article
- Acceleration index predicts efficacy of orthostatic training on postural orthostatic tachycardia syndrome in children.European journal of pediatrics · 2024Article
- [A 10-year retrospective analysis of spectrums and treatment options of orthostatic intolerance and sitting intolerance in children].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Clinical Efficacy of Empirical Therapy in Children with Vasovagal Syncope.Children (Basel, Switzerland) · 2022Article
- Spectrum of underlying diseases in syncope and treatment of neurally-mediated syncope in children and adolescents over the past 30 years: A single center study.Frontiers in cardiovascular medicine · 2022Article
- Baroreflex sensitivity predicts therapeutic effects of metoprolol on pediatric postural orthostatic tachycardia syndrome.Frontiers in cardiovascular medicine · 2022Article
- Transition of adult patients with pediatric orthostatic intolerance from child-centered care to adult-centered care.Frontiers in pediatrics · 2022Article
- Baseline Corrected QT Interval Dispersion Is Useful to Predict Effectiveness of Metoprolol on Pediatric Postural Tachycardia Syndrome.Frontiers in cardiovascular medicine · 2021Article
- Management of orthostatic intolerance in children: the state of the art.World journal of pediatrics : WJP · 2020Article
- Differential diagnosis of vasovagal syncope and postural tachycardia syndrome in children.World journal of pediatrics : WJP · 2020Article
- Sitting-induced hemodynamic changes and association with sitting intolerance in children and adolescents: a cross-sectional study.Scientific reports · 2020Article
- Update of Individualized Treatment Strategies for Postural Orthostatic Tachycardia Syndrome in Children.Frontiers in neurology · 2020Review
- Orthostatic Hypertension in Children: An Update.Frontiers in pediatrics · 2020Review
- Postural Tachycardia Syndrome in Children and Adolescents: Pathophysiology and Clinical Management.Frontiers in pediatrics · 2020Review
- Pubertal Hormonal Changes and the Autonomic Nervous System: Potential Role in Pediatric Orthostatic Intolerance.Frontiers in neuroscience · 2019Review
- Increased Endogenous Sulfur Dioxide Involved in the Pathogenesis of Postural Tachycardia Syndrome in Children: A Case-Control Study.Chinese medical journal · 2018Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to determine upright heart rate and blood pressure (BP) changes to suggest diagnostic criteria for postural orthostatic tachycardia syndrome (POTS) and orthostatic hypertension (OHT) in Chinese children.
methodsIn this cross-sectional study, 1449 children and adolescents aged 6-18 years were randomly recruited from two cities in China, Kaifeng in Henan province and Anguo in Hebei province. They were divided into two groups: 844 children aged 6-12 years (group I) and 605 adolescents aged 13-18 years (group II). Heart rate and BP were recorded during an active standing test.
results95th percentile (P(95)) of δ heart rate from supine to upright was 38 bpm, with a maximum upright heart rate of 130 and 124 bpm in group I and group II, respectively. P(95) of δ systolic blood pressure (SBP) increase was 18 mm Hg and P(95) of upright SBP was 132 mm Hg in group I and 138 mm Hg in group II. P(95) of δ diastolic blood pressure (DBP) increase was 24 mm Hg in group I and 21 mm Hg in group II, and P(95) of upright DBP was 89 mm Hg in group I and 91 mm Hg in group II.
conclusionsPOTS is suggested when δ heart rate is ≥ 38 bpm (for easy memory, ≥ 40 bpm) from supine to upright, or maximum heart rate ≥ 130 bpm (children aged 6-12 years) and ≥ 125 pm (adolescents aged 13-18 years), associated with orthostatic symptoms. OHT is suggested when δ SBP (increase) is ≥ 20 mm Hg, and/or δ DBP (increase) ≥ 25 mm Hg (in children aged 6-12 years) or ≥ 20 mm Hg (in adolescents aged 13-18 years) from supine to upright; or upright BP ≥ 130/90 mm Hg (in children aged 6-12 years) or ≥ 140/90 mm Hg (in adolescents aged 13-18 years).
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