ArticleJournal of diabetes science and technology2015
The Development of a Continuous Intravascular Glucose Monitoring Sensor.
Article in Journal of diabetes science and technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline.Journal of diabetes science and technology · 2020Guideline
- Recent Advances in Micro- and Nano-Enhanced Intravascular Biosensors for Real-Time Monitoring, Early Disease Diagnosis, and Drug Therapy Monitoring.Sensors (Basel, Switzerland) · 2025Review
- Design Principles of Nanosensors for Multiplex Detection of Contaminants in Food.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Fluorescent Chemosensors in the Creation of a Commercially Available Continuous Glucose Monitor.ACS sensors · 2024Article
- Accuracy of continuous glucose monitoring systems in intensive care unit patients: a scoping review.Intensive care medicine · 2024Article
- Synthesis, characterization, and biological activity of a fresh class of sonochemically synthesized CuScientific reports · 2024Article
- A New Boron-Rhodamine-Containing Carboxylic Acid as a Sugar Chemosensor.Sensors (Basel, Switzerland) · 2023Article
- Patient blood management in the ICU: A narrative review of the literature.European journal of anaesthesiology and intensive care · 2022Review
- Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids.Chemical reviews · 2022Review
- Avoidable Blood Loss in Critical Care and Patient Blood Management: Scoping Review of Diagnostic Blood Loss.Journal of clinical medicine · 2022Article
- Fluorescent Nanozeolite Receptors for the Highly Selective and Sensitive Detection of Neurotransmitters in Water and Biofluids.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Molecular Boronic Acid-Based Saccharide Sensors.ACS sensors · 2021Review
- Monitoring with In Vivo Electrochemical Sensors: Navigating the Complexities of Blood and Tissue Reactivity.Sensors (Basel, Switzerland) · 2020Review
- Accuracy and stability of an arterial sensor for glucose monitoring in a porcine model using glucose clamp technique.Scientific reports · 2020Article
- Managing hyperglycemia during the COVID-19 pandemic: Improving outcomes using new technologies in intensive care.SAGE open medicine · 2020Review
- The mechanisms of boronate ester formation and fluorescent turn-on in ortho-aminomethylphenylboronic acids.Nature chemistry · 2019Review
- Glucose Management Technologies for the Critically Ill.Journal of diabetes science and technology · 2019Review
- Article
- Designing the Glucose Telemetry for Hospital Management: From Bedside to the Nursing Station.Current diabetes reports · 2018Review
- Glucose-sensitive silicone hydrogel contact lens toward tear glucose monitoring.Journal of biomedical optics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlycemic control in hospital intensive care units (ICU) has been the subject of numerous research publications and debate over the past 2 decades. There have been multiple studies showing the benefit of ICU glucose control in reducing both morbidity and mortality. GlySure Ltd has developed a glucose monitor based on a diboronic acid receptor that can continuously measure plasma glucose concentrations directly in a patient's vascular system. The goal of this study was to validate the performance of the GlySure CIGM system in different patient populations.
methodsThe GlySure Continuous Intravascular Glucose Monitoring (CIGM) System was evaluated in both the Cardiac ICU (33 patients) and MICU setting (14 patients). The sensor was placed through a custom CVC and measured the patients' blood glucose concentration every 15 seconds. Comparison blood samples were taken at 2 hourly then 4 hourly intervals and measured on a YSI 2300 STAT Plus or an i-STAT.
resultsConsensus error grid analysis of the data shows that the majority of the data (88.2% Cardiac, and 95.0% MICU) fell within zone A, which is considered to be clinically accurate and all data points fell within zones A and B. The MARD of the Cardiac trial was 9.90% and the MICU trial had a MARD of 7.95%. Data analysis showed no significant differences between data generated from Cardiac and MICU patients or by time or glucose concentration.
conclusionsThe GlySure CIGM System has met the design challenges of measuring intravascular glucose concentrations in critically ill patients with acceptable safety and performance criteria and without disrupting current clinical practice. The accuracy of the data is not affected by the patients' condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.