ReviewBirth defects research. Part A, Clinical and molecular teratology2015
The National Birth Defects Prevention Study: A review of the methods.
Review in Birth defects research. Part A, Clinical and molecular teratology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
173 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A genome-wide association study implicates the BMP7 locus as a risk factor for nonsyndromic metopic craniosynostosis.Human genetics · 2020Pooled it
- Maternal Smoking and Preterm Birth Among Infants With Orofacial Clefts.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Registered Prevalence and Regional Characteristics of Congenital Anomalies in the Turkistan Region.International journal of environmental research and public health · 2026Article
- Cannabis use, preterm birth, and small for gestational age: findings from the national birth defects prevention study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Maternal Fish Intake in the Year Prior to Conception and Birth Defects, National Birth Defects Prevention Study, 1997-2011.Birth defects research · 2026Article
- Assessing the Impact of Exposure Misclassification in Case-Control Studies of Self-Reported Medication Use.Paediatric and perinatal epidemiology · 2026Article
- Maternal Myo-Inositol Intake and Congenital Heart Defects in Offspring: A Population-Based Case-Control Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Evaluating Differences in Nonsyndromic Orofacial Clefts by Infant Sex: National Birth Defects Prevention Study, 1997-2011.The Journal of pediatrics · 2026Article
- Association between maternal occupation as a cleaner/maid/janitor during early pregnancy and selected birth defects in the National Birth Defects Prevention Study.Occupational and environmental medicine · 2025Article
- Maternal Folic Acid Supplement Use, Folate Intake, and Preterm Birth Among Infants With Spina Bifida.Birth defects research · 2025Article
- Maternal occupational exposure to noise: prevalence, maternal effects and infant outcomes in the National Birth Defects Prevention Study, 1997-2011.Occupational and environmental medicine · 2025Article
- Maternal Age Differences in Interpregnancy Interval and Preterm Birth Associations Accounting for Multiple Epidemiologic Biases.Paediatric and perinatal epidemiology · 2025Article
- Exome Sequencing to Identify Novel Susceptibility Genes for Nonsyndromic Split-Hand/Ft Malformation: A Report From the National Birth Defects Prevention Study.Birth defects research · 2025Article
- Using Residual Newborn Blood Spots to Investigate CpG Methylation in Relation to Air Pollution and Congenital Heart Defects.Birth defects research · 2025Article
- Global, regional, and national burdens of congenital heart anomalies from 1990 to 2021, and projections to 2050.Frontiers in pediatrics · 2025Article
- Classification of isolated versus multiple birth defects: An automated process for population-based registries.American journal of medical genetics. Part A · 2024Article
- Survival of Children With Critical Congenital Heart Defects in the National Birth Defects Prevention Study.Birth defects research · 2024Article
- Maternal Exposure to Tap Water Disinfection By-Products and Risk of Selected Congenital Heart Defects.Birth defects research · 2024Article
- Bias analyses to investigate the impact of differential participation: Application to a birth defects case-control study.Paediatric and perinatal epidemiology · 2024Article
- Exome sequencing identifies novel genes underlying primary congenital glaucoma in the National Birth Defects Prevention Study.Birth defects research · 2024Article
113 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
backgroundThe National Birth Defects Prevention Study (NBDPS) is a large population-based multicenter case-control study of major birth defects in the United States.
methodsData collection took place from 1998 through 2013 on pregnancies ending between October 1997 and December 2011. Cases could be live born, stillborn, or induced terminations, and were identified from birth defects surveillance programs in Arkansas, California, Georgia, Iowa, Massachusetts, New Jersey, New York, North Carolina, Texas, and Utah. Controls were live born infants without major birth defects identified from the same geographical regions and time periods as cases by means of either vital records or birth hospitals. Computer-assisted telephone interviews were completed with women between 6 weeks and 24 months after the estimated date of delivery. After completion of interviews, families received buccal cell collection kits for the mother, father, and infant (if living).
resultsThere were 47,832 eligible cases and 18,272 eligible controls. Among these, 32,187 (67%) and 11,814 (65%), respectively, provided interview information about their pregnancies. Buccal cell collection kits with a cytobrush for at least one family member were returned by 19,065 case and 6,211 control families (65% and 59% of those who were sent a kit). More than 500 projects have been proposed by the collaborators and over 200 manuscripts published using data from the NBDPS through December 2014.
conclusionThe NBDPS has made substantial contributions to the field of birth defects epidemiology through its rigorous design, including case classification, detailed questionnaire and specimen collection, large study population, and collaborative activities across Centers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.