ArticleMicrobiologyOpen2015
Quantitative analysis of commensal Escherichia coli populations reveals host-specific enterotypes at the intra-species level.
Article in MicrobiologyOpen, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
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- Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophage.Nature biotechnology · 2026Article
- Population structure and pathogen interaction of Escherichia coli in freshwater: Implications of land-use for water quality and public health in Aotearoa New Zealand.Environmental microbiology reports · 2024Article
- Under-Appreciated Phylogroup Diversity ofApplied and environmental microbiology · 2023Article
- Prevalence and molecular epidemiology ofFrontiers in microbiology · 2023Article
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- The Cytotoxic Necrotizing Factors (CNFs)-A Family of Rho GTPase-Activating Bacterial Exotoxins.Toxins · 2021Review
- Interplay between Bacterial Clones and Plasmids in the Spread of Antibiotic Resistance Genes in the Gut: Lessons from a Temporal Study in Veal Calves.Applied and environmental microbiology · 2021Article
- Phylum barrier andMicrobial genomics · 2021Article
- Antimicrobial Resistance Profile and ExPEC Virulence Potential in CommensalAntibiotics (Basel, Switzerland) · 2021Article
- The utility of Escherichia coli as a contamination indicator for rural drinking water: Evidence from whole genome sequencing.PloS one · 2021Article
- The population genetics of pathogenic Escherichia coli.Nature reviews. Microbiology · 2021Review
- Success of Escherichia coli O25b:H4 Sequence Type 131 Clade C Associated with a Decrease in Virulence.Infection and immunity · 2020Article
- Temporal dynamics of the fecal microbiota in veal calves in a 6-month field trial.Animal microbiome · 2020Article
- Phylogenetic background and habitat drive the genetic diversification of Escherichia coli.PLoS genetics · 2020Article
- Factors Obscuring the Role ofInternational journal of environmental research and public health · 2020Review
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- Captive Green Iguana Carries DiarrheagenicFrontiers in veterinary science · 2020Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary habitat of the Escherichia coli species is the gut of warm-blooded vertebrates. The E. coli species is structured into four main phylogenetic groups A, B1, B2, and D. We estimated the relative proportions of these phylogroups in the feces of 137 wild and domesticated animals with various diets living in the Ile de France (Paris) region by real-time PCR. We distinguished three main clusters characterized by a particular abundance of two or more phylogroups within the E. coli animal commensal populations, which we called "enterocolitypes" by analogy with the enterotypes defined in the human gut microbiota at the genus level. These enterocolitypes were characterized by a dominant (>50%) B2, B1, or A phylogroup and were associated with different host species, diets, and habitats: wild and herbivorous species (wild rabbits and deer), domesticated herbivorous species (domesticated rabbits, horses, sheep, and cows), and omnivorous species (boar, pigs, and chickens), respectively. By analyzing retrospectively the data obtained using the same approach from 98 healthy humans living in Ile de France (Smati et al. 2013, Appl. Environ. Microbiol. 79, 5005-5012), we identified a specific human enterocolitype characterized by the dominant and/or exclusive (>90%) presence of phylogroup B2. We then compared B2 strains isolated from animals and humans, and revealed that human and animal strains differ regarding O-type and B2 subgroup. Moreover, two genes, sfa/foc and clbQ, were associated with the exclusive character of strains, observed only in humans. In conclusion, a complex network of interactions exists at several levels (genus and intra-species) within the intestinal microbiota.
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