ArticleJournal of neuro-oncology2015
Ex vivo confocal microscopy imaging to identify tumor tissue on freshly removed brain sample.
Article in Journal of neuro-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Review
- Confocal laser endomicroscopy in glial tumors-a histomorphological analysis.Neurosurgical review · 2024Article
- Rapid digital pathology of H&E-stained fresh human brain specimens as an alternative to frozen biopsy.Communications medicine · 2023Article
- Optical coherence tomography holds promise to transform the diagnostic anatomic pathology gross evaluation process.Journal of biomedical optics · 2022Article
- Ex vivo confocal microscopy performs real-time assessment of renal biopsy in non-neoplastic diseases.Journal of nephrology · 2021Article
- Confocal Laser Microscopy in Neurosurgery: State of the Art of Actual Clinical Applications.Journal of clinical medicine · 2021Review
- Confocal Laser Endomicroscopy Assessment of Pituitary Tumor Microstructure: A Feasibility Study.Journal of clinical medicine · 2020Article
- Compact and contactless reflectance confocal microscope for neurosurgery.Biomedical optics express · 2020Article
- Open-Top Light-Sheet Microscopy Image Atlas of Prostate Core Needle Biopsies.Archives of pathology & laboratory medicine · 2019Article
- Advances in the use of reflectance confocal microscopy in melanoma.Melanoma management · 2018Review
- Ex vivo confocal microscopy: an emerging technique in dermatology.Dermatology practical & conceptual · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Confocal microscopy is a technique able to realize "optic sections" of a tissue with increasing applications. We wondered if we could apply an ex vivo confocal microscope designed for dermatological purpose in a routine use for the most frequent brain tumors. The aim of this work was to identify tumor tissue and its histopathological hallmarks, and to assess grading criteria used in neuropathological practice without tissue loss on freshly removed brain tissue. Seven infiltrating gliomas, nine meningiomas and three metastases of carcinomas were included. We compared imaging results obtained with the confocal microscope to frozen sections, smears and tissue sections of formalin-fixed tissue. Our results show that ex vivo confocal microscopy imaging can be applied to brain tumors in order to quickly identify tumor tissue without tissue loss. It can differentiate tumors and can assess most of grading criteria. Confocal microscopy could represent a new tool to identify tumor tissue on freshly removed sample and could help in selecting areas for biobanking of tumor tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.