Evidence map›Paper›PMID 26033422›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2015

Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.

Adam D Celiz, James G W Smith, Asha K Patel, Andrew L Hook, Divya Rajamohan, Vinoj T George, Luke Flatt, Minal J Patel, Vidana C Epa, Taranjit Singh and 10 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
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  12. Harnessing biomolecules for bioinspired dental biomaterials.Journal of materials chemistry. B · 2020
    Review
  13. Article
  14. Article
  15. Review
  16. Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array.Journal of visualized experiments : JoVE · 2018
    Article
  17. Designing stem cell niches for differentiation and self-renewal.Journal of the Royal Society, Interface · 2018
    Review
  18. Article
  19. Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis.Molecular therapy : the journal of the American Society of Gene Therapy · 2018
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 3 countries.

Adam D CelizLaboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
James G W SmithWolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Asha K PatelWolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Andrew L HookLaboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Divya RajamohanWolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Vinoj T GeorgeWolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Luke FlattWolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Minal J PatelWolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Vidana C EpaCSIRO Manufacturing Flagship, 343 Royal Parade, Parkville, 3052, Australia.
Taranjit SinghLaboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Robert LangerDavid H. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Daniel G AndersonDavid H. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Nicholas D AllenCardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
David C HayMRC Centre for Regenerative Medicine SCRM Building, The University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
David A WinklerCSIRO Manufacturing Flagship, Bayview Avenue, Clayton, 3168, Australia.
David A BarrettCentre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Martyn C DaviesLaboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Lorraine E YoungWolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Chris DenningWolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Morgan R AlexanderLaboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
University of Nottingham · GBMassachusetts Institute of Technology · USCardiff University · GBCSIRO Manufacturing · AUMolecular Research Institute · USMRC Centre for Regenerative Medicine · GB

Funding

Biotechnology and Biological Sciences Research Council BB/E006159/1Biotechnology and Biological Sciences Research Council BB/G010390/1Biotechnology and Biological Sciences Research Council BB/G021821/1Biotechnology and Biological Sciences Research Council BBS/B/06164British Heart Foundation PG/09/027/27141Medical Research Council G0801098Medical Research Council G113/30Medical Research Council MR/K026666/1Medical Research Council MR/L022974/1Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C013105/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C013202/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/K000225/1
6 · The paper itself

Abstract

A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.

Indexed as

PolymersCell AdhesionCell Culture TechniquesCell DifferentiationCell LineCell LineageCulture MediaFluorescent Antibody TechniqueHigh-Throughput Screening AssaysHumansMicroarray AnalysisPluripotent Stem CellsCulture MediaPolymershigh throughputhuman pluripotent stem cellsmaterials discoverypolymer microarraysstem cell differentiation

Identifiers

PMID26033422
PMCPMC4862031
OpenAlexW1864688359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.