ArticleMagnetic resonance in medicine2016
UCEPR: Ultrafast localized CEST-spectroscopy with PRESS in phantoms and in vivo.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Ultrafast Z-spectroscopic imaging in vivo at 3T using through-slice spectral encoding (TS-UFZ).Magnetic resonance in medicine · 2023Article
- In vivo detection of carnosine and its derivatives using chemical exchange saturation transfer.Magnetic resonance in medicine · 2022Article
- Angiopep-2 as an Exogenous Chemical Exchange Saturation Transfer Contrast Agent in Diagnosis of Alzheimer's Disease.Journal of healthcare engineering · 2022Article
- Development of fast multi-slice apparent TMagnetic resonance in medicine · 2021Article
- Article
- Development of intravoxel inhomogeneity correction for chemical exchange saturation transfer spectral imaging: a high-resolution field map-based deconvolution algorithm for magnetic field inhomogeneity correction.Magnetic resonance in medicine · 2020Article
- CEST, ASL, and magnetization transfer contrast: How similar pulse sequences detect different phenomena.Magnetic resonance in medicine · 2018Review
- Clinical applications of chemical exchange saturation transfer (CEST) MRI.Journal of magnetic resonance imaging : JMRI · 2018Review
- Chemical exchange saturation transfer (CEST) imaging with fast variably-accelerated sensitivity encoding (vSENSE).Magnetic resonance in medicine · 2017Article
- Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy.Analytical chemistry · 2016Article
- Localized, gradient-reversed ultrafast z-spectroscopy in vivo at 7T.Magnetic resonance in medicine · 2016Article
- Screening CEST contrast agents using ultrafast CEST imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2016Article
- CEST theranostics: label-free MR imaging of anticancer drugs.Oncotarget · 2016Article
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Authors and funding
5 authors.
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Abstract
purposeChemical exchange saturation transfer (CEST) is a contrast mechanism enhancing low-concentration molecules through saturation transfer from their exchangeable protons to bulk water. Often many scans are acquired to form a Z-spectrum, making the CEST method time-consuming. Here, an ultrafast localized CEST-spectroscopy with PRESS (UCEPR) is proposed to obtain the entire Z-spectrum of a voxel using only two scans, significantly accelerating CEST. THEORY AND
methodsThe approach combines ultrafast nonlocalized CEST spectroscopy with localization using PRESS. A field gradient is applied concurrently with the saturation pulse producing simultaneous saturation of all Z-spectrum frequencies that are also spatially encoded. A readout gradient during data acquisition resolves the spatial dependence of the CEST responses into frequency. UCEPR was tested on a 3T scanner both in phantoms and in vivo.
resultsIn phantoms, a fast Z-spectroscopy acquisition of multiple pH-variant iopamidol samples was achieved with four- to seven-fold acceleration as compared to the conventional CEST methods. In vivo, amide proton transfer (APT) in white matter of healthy human brain was measured rapidly in 48 s and with high frequency resolution (≤ 0.2 ppm).
conclusionCompared with conventional CEST methods, UCEPR has the advantage of rapidly acquiring high-resolution Z-spectra. Potential in vivo applications include ultrafast localized Z-spectroscopy, quantitative, or dynamic CEST studies.
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