ArticleMolecular and cellular endocrinology2015
Phosphorylation of Ser-279/282 and Tyr-265 positions on Cx43 as possible mediators of VEGF-165 inhibition of pregnancy-adapted Ca2+ burst function in ovine uterine artery endothelial cells.
Article in Molecular and cellular endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- TNF but not VEGF induces secretion of multiple chemokines and cytokines by uterine artery endothelial cells: potential implications for preeclampsia.Journal of molecular endocrinology · 2025Article
- Src kinase partially mediates cytokine-induced endothelial dysfunction.Pregnancy hypertension · 2023Article
- The epidermal growth factor receptor in healthy pregnancy and preeclampsia.Journal of molecular endocrinology · 2023Review
- The Role of Connexin in Ophthalmic Neovascularization and the Interaction between Connexin and Proangiogenic Factors.Journal of ophthalmology · 2022Review
- Vascular Dysfunction in Preeclampsia.Cells · 2021Review
- Differential control of uterine artery endothelial monolayer integrity by TNF and VEGF is achieved through multiple mechanisms operating inside and outside the cell - Relevance to preeclampsia.Molecular and cellular endocrinology · 2021Article
- Cytokine concentrations direct endothelial function in pregnancy and preeclampsia.The Journal of endocrinology · 2021Article
- Article
- Adenoviral transduction of EGFR into pregnancy-adapted uterine artery endothelial cells remaps growth factor induction of endothelial dysfunction.Molecular and cellular endocrinology · 2020Article
- TNF-alpha inhibits pregnancy-adapted CaMolecular and cellular endocrinology · 2019Article
- Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia.The Journal of endocrinology · 2017Review
- Positive versus negative effects of VEGF165 on Ca2+ signaling and NO production in human endothelial cells.American journal of physiology. Heart and circulatory physiology · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Normal pregnancy requires increased uterine endothelial cell driven vasodilation that is related to increases in sustained Ca2+ signaling via increased connexin 43 (Cx43) gap junction function. Preeclampsia, a hypertensive disorder of pregnancy associated with endothelial dysfunction, is also linked with down regulation of Ca2+ driven vasodilator production and increased levels of vascular endothelial growth factor (VEGF). Cx43 function can be acutely down-regulated by phosphorylation of multiple inhibitory residues and VEGF is known to promote phosphorylation of Cx43. Herein, we show that VEGF-165 promotes Cx43 phosphorylation at Ser-279/282 and Tyr-265 residues and blocks pregnancy-adapted Ca2+ signaling in ovine uterine artery endothelial cells (UAEC). Pharmacological Src and ERK kinase pathway inhibitors (PP2 and U0126) reverse these phosphorylations and rescue Ca2+ signaling. We also report a nutraceutical Src inhibitor, t10,c12 conjugated linoleic acid (10,12 CLA), rescues Ca2+ signaling in UAEC and therefore may have therapeutic potential for preeclampsia.
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