Evidence map›Paper›PMID 26033243›Full record

ArticleMolecular psychiatry2016

Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.

T G M van Erp, D P Hibar, J M Rasmussen, D C Glahn, G D Pearlson, O A Andreassen, I Agartz, L T Westlye, U K Haukvik, A M Dale and 49 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 550 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
550citing papers in PubMed, 11 pooled it
44.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

550 citing papers in PubMed, 11 syntheses or guidelines pooled it, 1,171 citations in OpenAlex.

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490 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

59 authors at 20 institutions in 11 countries.

T G M van ErpDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
D P HibarImaging Genetics Center, University of Southern California, Los Angeles, CA, USA.
J M RasmussenDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
D C GlahnDepartment of Psychiatry, Yale University, New Haven, CT, USA.
G D PearlsonDepartment of Psychiatry, Yale University, New Haven, CT, USA.
O A AndreassenNorwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
I AgartzNorwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
L T WestlyeNorwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
U K HaukvikNorwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
A M DaleMMIL, Department of Radiology, University of California, San Diego, CA, USA.
I MelleNorwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
C B HartbergNorwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
O GruberDepartment of Psychiatry, University Medical Center Göttingen, Göttingen, Germany.
B KraemerDepartment of Psychiatry, University Medical Center Göttingen, Göttingen, Germany.
D ZillesDepartment of Psychiatry, University Medical Center Göttingen, Göttingen, Germany.
G DonohoeCognitive Genetics and Therapy Group, School of Psychology, National University of Ireland, Galway, Ireland.
S KellyImaging Genetics Center, University of Southern California, Los Angeles, CA, USA.
C McDonaldClinical Neuroimaging Laboratory, College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland.
D W MorrisCognitive Genetics and Therapy Group, School of Psychology, National University of Ireland, Galway, Ireland.
D M CannonClinical Neuroimaging Laboratory, College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland.
A CorvinNeuropsychiatric Genetics research group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College, Dublin, Ireland.
M W J MachielsenAcademic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
L KoendersAcademic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
L de HaanAcademic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
D J VeltmanUniversity Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
T D SatterthwaiteDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
D H WolfDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
R C GurDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
R E GurDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
S G PotkinDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
D H MathalonDepartment of Psychiatry, University of California, San Francisco, CA, USA.
B A MuellerDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
A PredaDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-3373-2438
F MacciardiDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
S EhrlichTranslational Developmental Neuroscience Section, Department of Child and Adolescent Psychiatry, Technische Universität, Dresden, Germany.
E WaltonTranslational Developmental Neuroscience Section, Department of Child and Adolescent Psychiatry, Technische Universität, Dresden, Germany.
J HassTranslational Developmental Neuroscience Section, Department of Child and Adolescent Psychiatry, Technische Universität, Dresden, Germany.
V D CalhounMind Research Network, Albuquerque, NM, USA.
H J BockholtMind Research Network, Albuquerque, NM, USA.
S R SponheimMinneapolis VA Healthcare System & Department of Psychiatry, University of Minnesota, Twin Cities, MN, USA.
J M ShoemakerMind Research Network, Albuquerque, NM, USA.
N E M van HarenBrain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
H E Hulshoff PolBrain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
H E H PolBrain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
R A OphoffBrain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
R S KahnBrain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
R Roiz-SantiañezDepartment of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
B Crespo-FacorroDepartment of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
L WangDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.
K I AlpertDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.
E G JönssonNorwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
R DimitrovaDivision of Psychiatry, University of Edinburgh Medical School, Edinburgh, UK.
C BoisDivision of Psychiatry, University of Edinburgh Medical School, Edinburgh, UK.
H C WhalleyDivision of Psychiatry, University of Edinburgh Medical School, Edinburgh, UK.
A M McIntoshDivision of Psychiatry, University of Edinburgh Medical School, Edinburgh, UK.
S M LawrieDivision of Psychiatry, University of Edinburgh Medical School, Edinburgh, UK.
R HashimotoMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.ORCID http://orcid.org/0000-0002-5941-4238
P M ThompsonImaging Genetics Center, University of Southern California, Los Angeles, CA, USA.
J A TurnerMind Research Network, Albuquerque, NM, USA.
Oslo University Hospital · NOUniversity of California, Irvine · USUniversity of Edinburgh · GBOllscoil na Gaillimhe – University of Galway · IEUniversity of Pennsylvania · USUniversity of Southern California · USAmsterdam UMC Location University of Amsterdam · NLMind Research Network · USUniversitätsmedizin Göttingen · DEUniversity Medical Center Utrecht · NLNorthwestern University · USTechnische Universität Dresden · DEUniversidad de Cantabria · ESUniversity of Minnesota · USYale University · USHarvard University · USSan Francisco VA Medical Center · USThe University of Osaka · JPTrinity College · CAUniversity of California, Los Angeles · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
FUNCTION BIRNU24RR021992 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTKIN, STEVEN G · 2006 to 2010
$25.0M
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4M
Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI SUI, JING · 2012 to 2017
$14.3M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
Mining the Genomewide Scan: Genetic Profiles of Structural Loss in Schizophrenia: AD/ADRD supplementR01MH094524 · NIMH · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D, TURNER, JESS · 2012 to 2021
$6.3M
Informed Data-Driven Fusion of Behavior, Brain Function, and GenesR01EB005846 · NIBIB · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2005 to 2016
$5.5M
Unified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7M
SchizConnect: Large-Scale Schizophrenia Neuroimaging Data Mediation & FederationU01MH097435 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AMBITE, JOSE LUIS, POTKIN, STEVEN G · 2013 to 2016
$2.0M
Medical Research Council MR/K026992/1NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR001414NCRR NIH HHS P41 RR014075NCRR NIH HHS U24 RR021992NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB005846NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIBIB NIH HHS U54 EB020403NIGMS NIH HHS P20 GM103472NIMH NIH HHS K23 MH085096NIMH NIH HHS R01 MH094524NIMH NIH HHS R01 MH101111NIMH NIH HHS U01 MH097435Wellcome Trust 104036
6 · The paper itself

Abstract

The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical brain volumes that differentiated patients from controls, and ranked them according to their effect sizes. Compared with healthy controls, patients with schizophrenia had smaller hippocampus (Cohen's d=-0.46), amygdala (d=-0.31), thalamus (d=-0.31), accumbens (d=-0.25) and intracranial volumes (d=-0.12), as well as larger pallidum (d=0.21) and lateral ventricle volumes (d=0.37). Putamen and pallidum volume augmentations were positively associated with duration of illness and hippocampal deficits scaled with the proportion of unmedicated patients. Worldwide cooperative analyses of brain imaging data support a profile of subcortical abnormalities in schizophrenia, which is consistent with that based on traditional meta-analytic approaches. This first ENIGMA Schizophrenia Working Group study validates that collaborative data analyses can readily be used across brain phenotypes and disorders and encourages analysis and data sharing efforts to further our understanding of severe mental illness.

Indexed as

AdultBrainBrain MappingCase-Control StudiesFemaleFunctional LateralityHumansImage Processing, Computer-AssistedLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingProspective StudiesSchizophrenia

Identifiers

PMID26033243
PMCPMC4668237
OpenAlexW1876943069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.