ArticleMolecular neurobiology2016
Support of Nerve Conduction by Respiring Myelin Sheath: Role of Connexons.
Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Myelination sustains axonal bioenergetics by storing and consuming oxygen for aerobic metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A viewpoint about Lenadogene nolparvovec failing to meet its primary endpoint even though it permanently corrects the m.11778G>A mutation causative of LHON.Eye (London, England) · 2025Article
- Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLAThe Journal of membrane biology · 2025Article
- Boosting Microglial Lipid Metabolism via TREM2 Signaling by Biomimetic Nanoparticles to Attenuate the Sevoflurane-Induced Developmental Neurotoxicity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A Connexin-Based Biomarker Model Applicable for Prognosis and Immune Landscape Assessment in Lung Adenocarcinoma.Journal of oncology · 2022Article
- Myelin sheath and cyanobacterial thylakoids as concentric multilamellar structures with similar bioenergetic properties.Open biology · 2021Article
- Clemastine Ameliorates Perioperative Neurocognitive Disorder in Aged Mice Caused by Anesthesia and Surgery.Frontiers in pharmacology · 2021Article
- The aerobic mitochondrial ATP synthesis from a comprehensive point of view.Open biology · 2020Review
- Connexins in Lung Cancer and Brain Metastasis.Frontiers in oncology · 2020Review
- An update of the chemiosmotic theory as suggested by possible proton currents inside the coupling membrane.Open biology · 2019Review
- Evaluation of the Acquisition of the Aerobic Metabolic Capacity by Myelin, during its Development.Molecular neurobiology · 2016Article
- Functional Expression of Electron Transport Chain and FoF1-ATP Synthase in Optic Nerve Myelin Sheath.Neurochemical research · 2015Article
- Role of myelin sheath energy metabolism in neurodegenerative diseases.Neural regeneration research · 2015Article
- Oligodendrocyte Precursor Cells in Spinal Cord Injury: A Review and Update.BioMed research international · 2015Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, we have demonstrated that myelin conducts an extramitochondrial oxidative phosphorylation, hypothesizing a novel supportive role for myelin in favor of the axon. We have also hypothesized that the ATP produced in myelin could be transferred thought gap junctions. In this work, by biochemical, immunohistochemical, and electrophysiological techniques, the existence of a connection among myelin to the axon was evaluated, to understand how ATP could be transferred from sheath to the axoplasm. Data confirm a functional expression of oxidative phosphorylation in isolated myelin. Moreover, WB and immunohistochemistry on optic nerve slices show that connexins 32 and 43 are present in myelin and colocalize with myelin basic protein. Interestingly, addition of carbenoxolone or oleamide, two gap junction blockers, causes a decrease in oxidative metabolism in purified myelin, but not in mitochondria. Similar effects were observed on conduction speed in hippocampal Schaffer collateral, in the presence of oleamide. Confocal analysis of optic nerve slices showed that lucifer yellow (that only passes through aqueous pores) signal was found in both the sheath layers and the axoplasma. In the presence of oleamide, but not with oleic acid, signal significantly decreased in the sheath and was lost inside the axon. This suggests the existence of a link among myelin and axons. These results, while supporting the idea that ATP aerobically synthesized in myelin sheath could be transferred to the axoplasm through gap junctions, shed new light on the function of the sheath.
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