ArticleReproductive biology and endocrinology : RB&E2015
Changes in estrone and estradiol levels during follicle development: a retrospective large-scale study.
Article in Reproductive biology and endocrinology : RB&E, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Assessment of ovarian dysfunction induced by environmental toxins: a systematic review.Frontiers in public health · 2025Pooled it
- A closed vitrification system enables a murine ovarian follicle bank for high-throughput ovotoxicity screening, which identifies endocrine disrupting activity of microcystins.Reproductive toxicology (Elmsford, N.Y.) · 2020Pooled it
- Effects of dietary palygorskite supplementation on production performance and reproductive function of laying hens.Poultry science · 2026Article
- Spontaneous ovulation, hormonal profiles, and the impact of progesterone timing variation on outcomes in natural proliferative phase frozen embryo transfer cycles with single euploid blastocyst transfer.Journal of ovarian research · 2025Article
- Biological sex and age influence GS-9620 activity ex vivo.JCI insight · 2025Article
- Association of blood progesterone levels on trigger day and low oocyte retrieval in cases with polycystic ovary syndrome undergoing in-vitro fertilization: A prospective cohort study.International journal of reproductive biomedicine · 2025Article
- Transformation of the cyclohexane ring to the cyclopentane fragment of biologically active compounds.Beilstein journal of organic chemistry · 2025Review
- HIV-1 latency reversal and immune enhancing activity of IL-15 is not influenced by sex hormones.JCI insight · 2024Article
- A Dose-Response Study on Functional and Transcriptomic Effects of FSH on Ex Vivo Mouse Folliculogenesis.Endocrinology · 2024Article
- Exploring the association of ESR1 and ESR2 gene SNPs with polycystic ovary syndrome in human females: a comprehensive association study.Journal of ovarian research · 2024Article
- Risk factors for low oocyte retrieval in patients with polycystic ovarian syndrome undergoing in vitro fertilization.Reproductive biology and endocrinology : RB&E · 2023Article
- Roles of kisspeptin in IVF/ICSI-treated infertile women and in human granulosa cells.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- A Novel Fertility Indicator Equation Using Estradiol Levels for Assessment of Phase of the Menstrual Cycle.Medicina (Kaunas, Lithuania) · 2020Article
- Mitochondrial Function in Modulating Human Granulosa Cell Steroidogenesis and Female Fertility.International journal of molecular sciences · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe improved reagent for measuring estradiol (E2), the ST AIA-PACK iE2 reagent, has a higher specificity for the measurement of E2 levels than the original ST AIA-PACK E2 reagent, because of its lower cross-reactivity with estrone (E1). As we had E2 data obtained with either of the reagents, we analyzed changes in E1 and E2 levels during follicle development.
methodsThe study included 14371 serum hormone measurements from 4412 patients who underwent oocyte retrieval or frozen/thawed embryo transfer in natural cycle in vitro fertilization in Shinbashi YUME clinic, Tokyo, between June 2011 and May 2014. The age of the patients ranged from 24 to 48 year (mean and standard deviation, 39.8 ± 4.0 year). Patients were categorized into three age groups (<38 year, 38-40 year, and >40 year) and into 10 groups of largest follicle diameter from 11 to 20 mm, with 1-mm intervals. Serum E2 levels were measured in the follicular phase with either the ST AIA-PACK E2 reagent or the ST AIA-PACK iE2 reagent, and the data were compared. Also, for 26 randomly selected samples, E2 was measured using both reagents, together with E1 and E3, and the E1/E2 ratios were compared.
resultsE2 concentrations measured with the ST AIA-PACK iE2 reagent were significantly lower than those measured with the ST AIA-PACK E2 reagent in the largest follicle diameter category of 11-17 mm in the <38 year group, in the largest follicle diameter category of 11-18 mm in the 38-40 year group, and in the largest follicle diameter category of 11-15 mm in the >40 year group. The serum E1/E2 ratio in the 26 samples was 3.4 ± 1.1 and 0.7 ± 0.1 in the early follicular phase and in the ovulatory phase, respectively.
conclusionsThe difference between the E2 concentrations measured with the ST AIA-PACK E2 reagent and the ST AIA-PACK iE2 reagent tended to decrease as the follicle diameter increased, particularly in the older patients, which suggests E1 secretion is more abundant in the early follicular phase and in younger patients than in the ovulatory phase and in older patients.
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