ArticleHuman brain mapping2015
Decreased activity with increased background network efficiency in amnestic MCI during a visuospatial working memory task.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Task-based fMRI brain activation in mild cognitive impairment and Alzheimer's disease: an ALE meta-analysis.GeroScience · 2026Pooled it
- Physical activity improves the visual-spatial working memory of individuals with mild cognitive impairment or Alzheimer's disease: a systematic review and network meta-analysis.Frontiers in public health · 2024Pooled it
- MRI-Based Brain Signatures of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- Multimodal EEG and explainable machine learning characterize neuroticism-related neurodynamic heterogeneity in mild cognitive impairment during visuospatial working memory.Frontiers in aging neuroscience · 2026Article
- Exploration of working memory retrieval stage for mild cognitive impairment: time-varying causality analysis of electroencephalogram based on dynamic brain networks.Journal of neuroengineering and rehabilitation · 2025Article
- High-Frequency rTMS Improves Visual Working Memory in Patients With aMCI: A Cognitive Neural Mechanism Study.CNS neuroscience & therapeutics · 2025Article
- Cortical activation in elderly patients with Alzheimer's disease dementia during working memory tasks: a multichannel fNIRS study.Frontiers in aging neuroscience · 2024Article
- Switching between External and Internal Attention in Hippocampal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Visual Dysfunction in Parkinson's Disease.Brain sciences · 2023Review
- Effect of Visual Feedback on Behavioral Control and Functional Activity During Bilateral Hand Movement.Brain topography · 2023Article
- Article
- Neuropsychology of posteromedial parietal cortex and conversion factors from Mild Cognitive Impairment to Alzheimer's disease: systematic search and state-of-the-art review.Aging clinical and experimental research · 2022Review
- Task-related brain functional network reconfigurations relate to motor recovery in chronic subcortical stroke.Scientific reports · 2021Article
- Changes in Resting-State Functional Connectivity of Cerebellum in Amnestic Mild Cognitive Impairment and Alzheimer's Disease: A Case-Control Study.Frontiers in systems neuroscience · 2021Article
- Altered Static and Temporal Dynamic Amplitude of Low-Frequency Fluctuations in the Background Network During Working Memory States in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2019Article
- Alterations to task positive and task negative networks during executive functioning in Mild Cognitive Impairment.NeuroImage. Clinical · 2018Article
- Caffeine impact on working memory-related network activation patterns in early stages of cognitive decline.Neuroradiology · 2017Article
- Altered Distant Synchronization of Background Network in Mild Cognitive Impairment during an Executive Function Task.Frontiers in behavioral neuroscience · 2017Article
- The Effect of Apolipoprotein E ε4 (APOE ε4) on Visuospatial Working Memory in Healthy Elderly and Amnestic Mild Cognitive Impairment Patients: An Event-Related Potentials Study.Frontiers in aging neuroscience · 2017Article
- Frequency-Dependent Brain Regional Homogeneity Alterations in Patients with Mild Cognitive Impairment during Working Memory State Relative to Resting State.Frontiers in aging neuroscience · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have demonstrated the working memory impairment in patients with amnestic mild cognitive impairment (aMCI). However, the neurophysiological basis of the working memory deficit in aMCI is poorly understood. The aim of this study was to explore the abnormal activity during encoding and recognition procedures, as well as the reorganization of the background network maintaining the working memory state in aMCI. Using event-related fMRI during a visuospatial working memory task with three recognition difficulty levels, the task-related activations and network efficiency of the background network in 17 aMCI patients and 19 matched controls were investigated. Compared with cognitively healthy controls, patients with aMCI showed significantly decreased activity in the frontal and visual cortices during the encoding phase, while during the recognition phase, decreased activity was detected in the frontal, parietal, and visual regions. In addition, increased local efficiency was also observed in the background network of patients with aMCI. The results suggest patients with aMCI showed impaired encoding and recognition functions during the visuospatial working memory task, and may pay more effort to maintain the cognitive state. This study extends our understanding of the impaired working memory function in aMCI and provides a new perspective to investigate the compensatory mechanism in aMCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.