ReviewEnvironmental health perspectives2015
Screening for Chemical Contributions to Breast Cancer Risk: A Case Study for Chemical Safety Evaluation.
Review in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
- Application of the Key Characteristics Framework to Identify Potential Breast Carcinogens Using Publicly AvailableEnvironmental health perspectives · 2024Article
- The regulation of endocrine-disrupting chemicals to minimize their impact on health.Nature reviews. Endocrinology · 2023Review
- Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland.Reproductive toxicology (Elmsford, N.Y.) · 2022Review
- On the Utility of ToxCast-Based Predictive Models to Evaluate Potential Metabolic Disruption by Environmental Chemicals.Environmental health perspectives · 2022Review
- Application of anEnvironmental health perspectives · 2021Article
- Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment.Archives of toxicology · 2021Article
- Knowledge Organization Systems for Systematic Chemical Assessments.Environmental health perspectives · 2020Article
- The Mouse Mammary Gland: a Tool to Inform Adolescents About Environmental Causes of Breast Cancer.Journal of cancer education : the official journal of the American Association for Cancer Education · 2020Article
- Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective.Journal of the Endocrine Society · 2020Article
- Developmental exposure to a mixture of unconventional oil and gas chemicals: A review of experimental effects on adult health, behavior, and disease.Molecular and cellular endocrinology · 2020Review
- Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment.Environment international · 2019Review
- Endocrine-Mediated Mechanisms of Metabolic Disruption and New Approaches to Examine the Public Health Threat.Frontiers in endocrinology · 2019Review
- Breast cancer risk and serum levels of per- and poly-fluoroalkyl substances: a case-control study nested in the California Teachers Study.Environmental health : a global access science source · 2018Article
- Oxybenzone Alters Mammary Gland Morphology in Mice Exposed During Pregnancy and Lactation.Journal of the Endocrine Society · 2018Article
- Novel application of normalized pointwise mutual information (NPMI) to mine biomedical literature for gene sets associated with disease: use case in breast carcinogenesis.Computational toxicology (Amsterdam, Netherlands) · 2018Article
- Cosmetics and Cancer: Adverse Event Reports Submitted to the Food and Drug Administration.JNCI cancer spectrum · 2018Article
- BCScreen: A gene panel to test for breast carcinogenesis in chemical safety screening.Computational toxicology (Amsterdam, Netherlands) · 2018Article
- Article
- Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop.Toxicology in vitro : an international journal published in association with BIBRA · 2017Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundCurrent approaches to chemical screening, prioritization, and assessment are being reenvisioned, driven by innovations in chemical safety testing, new chemical regulations, and demand for information on human and environmental impacts of chemicals. To conceptualize these changes through the lens of a prevalent disease, the Breast Cancer and Chemicals Policy project convened an interdisciplinary expert panel to investigate methods for identifying chemicals that may increase breast cancer risk.
methodsBased on a review of current evidence, the panel identified key biological processes whose perturbation may alter breast cancer risk. We identified corresponding assays to develop the Hazard Identification Approach for Breast Carcinogens (HIA-BC), a method for detecting chemicals that may raise breast cancer risk. Finally, we conducted a literature-based pilot test of the HIA-BC.
resultsThe HIA-BC identifies assays capable of detecting alterations to biological processes relevant to breast cancer, including cellular and molecular events, tissue changes, and factors that alter susceptibility. In the pilot test of the HIA-BC, chemicals associated with breast cancer all demonstrated genotoxic or endocrine activity, but not necessarily both. Significant data gaps persist.
conclusionsThis approach could inform the development of toxicity testing that targets mechanisms relevant to breast cancer, providing a basis for identifying safer chemicals. The study identified important end points not currently evaluated by federal testing programs, including altered mammary gland development, Her2 activation, progesterone receptor activity, prolactin effects, and aspects of estrogen receptor β activity. This approach could be extended to identify the biological processes and screening methods relevant for other common diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.