ArticlePlant biotechnology journal2016
Metabolomic profiling and genomic analysis of wheat aneuploid lines to identify genes controlling biochemical pathways in mature grain.
Article in Plant biotechnology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Integrative multi-omics analysis uncovers the regulatory network of wheat grain development during grain filling.BMC plant biology · 2026Article
- Seed Metabolomic Landscape Reflecting Key Differential Metabolic Profiles Among Different Wheat Cultivars.Metabolites · 2025Article
- Exploring seed characteristics and performance through advanced physico-chemical techniques.Scientific reports · 2024Article
- Integrated transcriptomic, proteomic and metabolomic analyses revealing the roles of amino acid and sucrose metabolism in augmenting drought tolerance inFrontiers in plant science · 2024Article
- Wheat Omics: Advancements and Opportunities.Plants (Basel, Switzerland) · 2023Review
- Mass Spectroscopy as an Analytical Tool to Harness the Production of Secondary Plant Metabolites: The Way Forward for Drug Discovery.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Widely untargeted metabolomic profiling unearths metabolites and pathways involved in leaf senescence and N remobilization in spring-cultivated wheat under different N regimes.Frontiers in plant science · 2023Article
- IMUP and GPRC5A: two newly identified risk score indicators in pancreatic ductal adenocarcinoma.Cancer cell international · 2021Article
- Plants Metabolome Study: Emerging Tools and Techniques.Plants (Basel, Switzerland) · 2021Review
- Exploitation of Drought Tolerance-Related Genes for Crop Improvement.International journal of molecular sciences · 2021Review
- Metabolomics as a Tool to Elucidate the Sensory, Nutritional and Safety Quality of Wheat Bread-A Review.International journal of molecular sciences · 2021Review
- Spatial distribution of proteins and metabolites in developing wheat grain and their differential regulatory response during the grain filling process.The Plant journal : for cell and molecular biology · 2021Article
- Comprehensive profiling of semi-polar phytochemicals in whole wheat grains (Triticum aestivum) using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Article
- Promoting Human Nutrition and Health through Plant Metabolomics: Current Status and Challenges.Biology · 2020Review
- The adaptation strategies of Herpetospermum pedunculosum (Ser.) Baill at altitude gradient of the Tibetan plateau by physiological and metabolomic methods.BMC genomics · 2019Article
- Omics Approaches for Engineering Wheat Production under Abiotic Stresses.International journal of molecular sciences · 2018Review
- Analysis of aneuploid lines of bread wheat to map chromosomal locations of genes controlling root hair length.Annals of botany · 2017Article
- Systems biology of seeds: deciphering the molecular mechanisms of seed storage, dormancy and onset of germination.Plant cell reports · 2017Article
- Metabolomics for Plant Improvement: Status and Prospects.Frontiers in plant science · 2017Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolomics is becoming an increasingly important tool in plant genomics to decipher the function of genes controlling biochemical pathways responsible for trait variation. Although theoretical models can integrate genes and metabolites for trait variation, biological networks require validation using appropriate experimental genetic systems. In this study, we applied an untargeted metabolite analysis to mature grain of wheat homoeologous group 3 ditelosomic lines, selected compounds that showed significant variation between wheat lines Chinese Spring and at least one ditelosomic line, tracked the genes encoding enzymes of their biochemical pathway using the wheat genome survey sequence and determined the genetic components underlying metabolite variation. A total of 412 analytes were resolved in the wheat grain metabolome, and principal component analysis indicated significant differences in metabolite profiles between Chinese Spring and each ditelosomic lines. The grain metabolome identified 55 compounds positively matched against a mass spectral library where the majority showed significant differences between Chinese Spring and at least one ditelosomic line. Trehalose and branched-chain amino acids were selected for detailed investigation, and it was expected that if genes encoding enzymes directly related to their biochemical pathways were located on homoeologous group 3 chromosomes, then corresponding ditelosomic lines would have a significant reduction in metabolites compared with Chinese Spring. Although a proportion showed a reduction, some lines showed significant increases in metabolites, indicating that genes directly and indirectly involved in biosynthetic pathways likely regulate the metabolome. Therefore, this study demonstrated that wheat aneuploid lines are suitable experimental genetic system to validate metabolomics-genomics networks.
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