Evidence map›Paper›PMID 26032095›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015

Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy.

Gui-Ming Zhang, Yao Zhu, Lei Luo, Fang-Ning Wan, Yi-Ping Zhu, Li-Jiang Sun, Ding-Wei Ye

Abstract read
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In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 13 pooled it
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 13 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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  8. The lymphocyte-to-monocyte ratio as a prognostic indicator in head and neck cancer: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gui-Ming ZhangDepartment of Urology, Fudan University Shanghai Cancer Center, No. 270, Dongan Rd., Shanghai, 200023, People's Republic of China.
Yao ZhuDepartment of Urology, Fudan University Shanghai Cancer Center, No. 270, Dongan Rd., Shanghai, 200023, People's Republic of China.
Lei LuoDepartment of Urology, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Rd., Qingdao, Shandong, 266003, People's Republic of China.
Fang-Ning WanDepartment of Urology, Fudan University Shanghai Cancer Center, No. 270, Dongan Rd., Shanghai, 200023, People's Republic of China.
Yi-Ping ZhuDepartment of Urology, Fudan University Shanghai Cancer Center, No. 270, Dongan Rd., Shanghai, 200023, People's Republic of China.
Li-Jiang SunDepartment of Urology, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Rd., Qingdao, Shandong, 266003, People's Republic of China. slijiang999@126.com.
Ding-Wei YeDepartment of Urology, Fudan University Shanghai Cancer Center, No. 270, Dongan Rd., Shanghai, 200023, People's Republic of China. yedingwei1963@126.com.
Shanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although pretreatment neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), and platelet-lymphocyte ratio (PLR) are reportedly associated with clinical outcomes of many cancers, their roles in patients with bladder cancer (BCa) who undergo radical cystectomy (RC) have not been widely investigated. We analyzed relationships between preoperative NLR, LMR, PLR, and overall survival (OS) in 124 BCa patients undergoing RC. OS curves were drawn using the Kaplan-Meier method and evaluated using the log-rank test. Relationships between OS and potential confounding variables were determined using Cox's proportional hazard regression model. Decreased LMR was associated with shorter OS (P = 0.012); OS in the low PLR group was significantly longer than that in the high PLR group (P = 0.029), and NLR was not significantly associated with oncological outcomes. However, after adjusting for confounding variables, patients in the high-LMR group indicated >30% decreased mortality than the low-LMR group (hazard ratio 0.674; 95% confidence interval 0.412-0.890; P = 0.003), and PLR was not an independent predictor of OS. Our results show that preoperative LMR is a better prognostic factor in BCa patients undergoing RC, compared with NLR and PLR.

Indexed as

PrognosisAgedAged, 80 and overBlood PlateletsCystectomyDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateLeukocyte CountLymphocytesMaleMiddle AgedMonocytesNeutrophilsPreoperative PeriodBladder cancerLMRNLRPLRPrognosisRadical cystectomy

Identifiers

PMID26032095
OpenAlexW2113202642

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.