ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
TKTL1 expression and its downregulation is implicated in cell proliferation inhibition and cell cycle arrest in esophageal squamous cell carcinoma.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 20 citations in OpenAlex.
- Epitope detection in monocytes (EDIM) for liquid biopsy including identification of GD2 in childhood neuroblastoma-a pilot study.British journal of cancer · 2022Article
- Tolerance of Human Fibroblasts to Benfo-Oxythiamine In Vitro.International journal of environmental research and public health · 2022Article
- TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression.International journal of molecular sciences · 2022Article
- Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation.Cell death & disease · 2022Article
- Transketolase Serves as a Biomarker for Poor Prognosis in Human Lung Adenocarcinoma.Journal of Cancer · 2022Article
- Prognostic values of transketolase family genes in ovarian cancer.Oncology letters · 2019Article
- Proteomic characterization of primary cultured myocytes in a fish model at different myogenesis stages.Scientific reports · 2019Article
- APC/CNature communications · 2019Article
- Evidence for transketolase-like TKTL1 flux in CHO cells based on parallel labeling experiments and (13)C-metabolic flux analysis.Metabolic engineering · 2016Article
- Evaluation of a biomarker based blood test for monitoring surgical resection of oral squamous cell carcinomas.Clinical oral investigations · 2016Article
- Gene expression profile of human esophageal squamous carcinoma cell line TE-1.International journal of clinical and experimental medicine · 2015Article
- Circular RNAs With Efficacy in PreclinicalCancer genomics & proteomicsArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that tumor cells mainly depend on the nonoxidative pathway of the pentose phosphate pathway (PPP), and transketolase-like 1 (TKTL1), a kind of crucial metabolism enzyme, participates in the regulation of PPP; notably, overwhelming evidence has demonstrated that TKTL1 plays pivotal roles in the development and progression of multiple tumors. However, there were no reports about the role of TKTL1 in esophageal squamous cell carcinoma (ESCC). Here, we investigated TKTL1 expression and preliminarily elucidated its underlying biological functions in ESCC. We found that TKTL1 exhibited the high expression in ESCC tissues and cells, and the survival rate of patients with negative TKTL1 expression was significantly higher than that of patients with positive TKTL1 staining (P < 0.05). Additionally, significant correlations of TKTL1 expression with histologic grade, clinical stage, and lymph node metastasis were found (P < 0.05). Subsequently, TKTL1 small interfering RNA (siRNA) significantly reduced TKTL1 messenger RNA (mRNA), and protein levels companied with the marked reduce of total transketolase activity but did not affect TKT and TKTL1 mRNA level. More importantly, TKTL1 siRNA obviously induced cell cycle arrest in G0/G1 phase and suppressed cell proliferation in vitro and in vivo coupled with the reduced cyclin D1 and cdk4 levels as well as decrease of Ki-67 proliferation index in EC1 cells. Taken altogether, our results suggest that TKTL1 as a key prognostic factor may be a novel target for therapy of the patients with ESCC.
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