Observational studyClinical medicine (London, England)2015
Blood alanine aminotransferase levels >1,000 IU/l - causes and outcomes.
Observational study in Clinical medicine (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- An Unexpected Cause of Extreme Hyperbilirubinemia and Acute Renal Failure: A Case of Weil's Disease in Poland.Cureus · 2026Article
- Normothermic perfusion of human livers for profiling lentiviral vector pharmacokinetics and transduction.Molecular therapy. Advances · 2026Article
- Multi-compartment profiling of donor-derived microRNAs during liver graft procurement: a prospective feasibility study.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- The impact of pathological fluctuations versus biological variation on the interpretation of laboratory values.Practical laboratory medicine · 2025Article
- Discovering Heterogeneous Leukocytes Subsets Associated With Alcoholic Steatohepatitis by scRNAseq Analysis.MedComm · 2025Article
- The emerging role of alternatively activated macrophages to treat acute liver injury.Archives of toxicology · 2025Review
- Autoimmune Hepatitis and Systemic Lupus Erythematosus Overlap Syndrome: A Case Report and Literature Review.Cureus · 2024Article
- Etiology and Outcomes of Patients with Extreme Hyperbilirubinemia in Korea: A Retrospective Cohort Study.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024Observational
- Association between exposure to a mixture of organochlorine pesticides and hyperuricemia in U.S. adults: A comparison of four statistical models.Eco-Environment & Health · 2024Article
- Effects of different levels of egg protein replacement in weaned diets on hematology, kidney functions, and immunity biomarkers.Food science & nutrition · 2023Article
- Markedly Elevated Aspartate Aminotransferase from Non-Hepatic Causes.Journal of clinical medicine · 2022Article
- A rare case of acute liver failure with intrahepatic cholestasis due to dengue hemorrhagic fever: CytoSorb® and plasma exchange aided in the recovery: case report.BMC infectious diseases · 2022Article
- Microfluidic system for near-patient extraction and detection of miR-122 microRNA biomarker for drug-induced liver injury diagnostics.Biomicrofluidics · 2022Article
- Effects of broccoli sprout supplements enriched in glucoraphanin on liver functions in healthy middle-aged adults with high-normal serum hepatic biomarkers: A randomized controlled trial.Frontiers in nutrition · 2022Article
- Article
- Enzymatic characterization of D-lactate dehydrogenase and application in alanine aminotransferase activity assay kit.Bioengineered · 2021Article
- Epidemiology and outcomes of marked elevations of alanine aminotransferase >1000 IU/L in an Australian cohort.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Mechanisms and biomarkers of liver regeneration after drug-induced liver injury.Advances in pharmacology (San Diego, Calif.) · 2019Review
- Biomarkers of drug-induced liver injury.Advances in pharmacology (San Diego, Calif.) · 2019Review
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Standard medical education dictates that the vast majority of cases of an alanine aminotransferase (ALT) level >1,000 IU/l will be due to acute ischaemia, acute drug-induced liver injury (DILI) (usually paracetamol) or acute viral hepatitis. There are very few references in the literature to other potential causes of an ALT >1,000 IU/l nor to the prognosis ascribed to each aetiology. In this study, we have confirmed that the main causes of a dramatic ALT rise are ischaemic liver injury, DILI and viral hepatitis. Common bile duct stones and hepatitis E are two causes for which there needs to be a high index of suspicion as the necessary tests may not be in the clinician's first-line investigation panel. Failing to find a cause and determining that the cause was ischaemic both have poor prognostic implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.