ReviewPhytotherapy research : PTR2015
Anti-diabetic and Anti-hyperlipidemic Effects and Safety of Salacia reticulata and Related Species.
Review in Phytotherapy research : PTR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Trial
- Antihyperglycemic and Antioxidant Effects ofPharmaceutics · 2026Article
- Acute and chronic toxicity study for Madhumukthi Kudineer Chooranum.Protoplasma · 2025Article
- Article
- Article
- Salacia spp.: recent insights on biotechnological interventions and future perspectives.Applied microbiology and biotechnology · 2024Review
- Traditional Herbal Medications Utilized in the Indian Medical System forthe Management of Diabetes: An Updated Review and Clinical Implications.Current diabetes reviews · 2024Review
- Article
- A randomized, double-blind clinical trial of a herbal formulation (GlycaCare-II) for the management of type 2 diabetes in comparison with metformin.Diabetology & metabolic syndrome · 2021Article
- A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia.Journal of natural medicines · 2021Review
- Antidiabetic Activity of Widely Used Medicinal Plants in the Sri Lankan Traditional Healthcare System: New Insight to Medicinal Flora in Sri Lanka.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Natural Hydrogen Sulfide Donors fromNutrients · 2019Review
- Review
- Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects.British journal of pharmacology · 2017Review
- Mangiferin protects against adverse skeletal muscle changes and enhances muscle oxidative capacity in obese rats.PloS one · 2017Article
- A Review of Natural Stimulant and Non-stimulant Thermogenic Agents.Phytotherapy research : PTR · 2016Review
- Anti-diabetic and Anti-hyperlipidemic Effects and Safety of Salacia reticulata and Related Species.Phytotherapy research : PTR · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracts of Salacia reticulata Wight (Hypocrataceae) roots, stems, and leaves have been used in Asia for hundreds of years for the folkloric treatment of diabetes and other health problems. Constituents that have been identified as exhibiting anti-diabetic effects include salacinol, kotalanol, ponkorinol, salaprinol, and their corresponding de-0-sulfonated compounds. Mangiferin, kotalagenin 16-acetate and various proanthocyanidin oligomers have also been isolated. Studies indicate that Salacia extracts modulate multiple targets that influence carbohydrate and lipid metabolism including α-glucosidase, aldose reductase, pancreatic lipase, peroxisomal proliferator-activated receptor-α, glucose transporter-4 mediated glucose uptake, and angiotensin II type 1 receptor. Furthermore, Salacia extracts exhibit free radical scavenging, antioxidant and hepatoprotectant activities. In human studies, Salacia extracts have been shown to decrease plasma glucose and insulin levels, decrease HbA1c, and modulate serum lipid levels with no adverse effects being reported. Similar results have been demonstrated in rat and mouse models as well as in vitro systems. Safety of S. reticulata and other Salacia species as S. oblonga and S. chinensis in rats and mice indicate that extracts are exceedingly safe. No clinical studies have examined the effects of Salacia extracts on human weight loss, although weight loss and decreases in weight gain have been demonstrated in animal models. Because of the large number of pharmacologically active compounds, it is difficult to establish standards for extracts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.