ArticleToxicology in vitro : an international journal published in association with BIBRA2015
Systematic in vitro toxicological screening of gold nanoparticles designed for nanomedicine applications.
Article in Toxicology in vitro : an international journal published in association with BIBRA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
- Advances in Nanomedicine: Transforming Diagnostic Imaging with Novel Contrast Agents.Current drug metabolism · 2025Review
- Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models.The Journal of clinical investigation · 2023Article
- Gold nanoparticles combat enveloped RNA virus by affecting organelle dynamics.Signal transduction and targeted therapy · 2023Article
- Metabolic Disruption of Gold Nanospheres, Nanostars and Nanorods in Human Metastatic Prostate Cancer Cells.Cells · 2023Article
- Influence of Cell Type on the Efficacy of Plasmonic Photothermal Therapy.ACS nanoscience Au · 2022Article
- In Vitro Evaluation of Anti-Rotaviral Activity and Intestinal Toxicity of a Phytotherapeutic Prototype ofViruses · 2022Article
- Clinical Feasibility Study of Gold Nanoparticles as Theragnostic Agents for Precision Radiotherapy.Biomedicines · 2022Article
- Detecting and Monitoring Hydrogels with Medical Imaging.ACS biomaterials science & engineering · 2021Review
- A detailed experimental and Monte Carlo analysis of gold nanoparticle dose enhancement using 6 MV and 18 MV external beam energies in a macroscopic scale.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2021Article
- Physico-Chemical Characterization and Assessment of Cytotoxic and Genotoxic Effects of Poly-Ethylene-Glycol Coated and Uncoated Gold Nanoparticles on Human Kidney (HK-2) Cells.Austin journal of environmental toxicology · 2021Article
- Comparison of Rhenium and Iodine as Contrast Agents in X-Ray Imaging.Contrast media & molecular imaging · 2021Article
- Critical Antileishmanial in vitro Effects of Highly Examined Gold Nanoparticles.International journal of nanomedicine · 2021Article
- Article
- A detailed Monte Carlo evaluation ofPhysics in medicine and biology · 2020Article
- Characterization and comparison of imaging contrast enhancement with PEG-functionalized gold nanoparticles in kV cone beam computed tomography and computed tomography imaging.Biomedical physics & engineering express · 2020Article
- Shape Matters: Comprehensive Analysis of Star-Shaped Lipid Nanoparticles.Frontiers in pharmacology · 2020Article
- Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography.Scientific reports · 2019Article
- Dextran-Coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Localized and pH-Activated Biofilm Disruption.ACS nano · 2019Article
- Multicolour imaging with spectral photon-counting CT: a phantom study.European radiology experimental · 2018Article
- Toxicology of Engineered Nanoparticles: Focus on Poly(amidoamine) Dendrimers.International journal of environmental research and public health · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Gold nanoparticles (AuNP) are increasingly being applied in the biomedical field as therapeutics, contrast agents, and in diagnostic systems, motivating investigations of their toxicity that might arise from accidental exposure. While other work has investigated the toxicological response to gold nanoparticles for industrial purposes, here we have surveyed formulations that have been developed for biomedical use, are in clinical trials or have been FDA-approved. The AuNP library tested contains a range of shapes, including spheres, rods and shells, that possess a range of coatings, such as silica, citrate, lipoprotein, polymaleic acid, polyethylene glycol, DNA and others. Good cytocompatibility for all formulations was observed after 1 h of incubation. However after 24 h exposure, a nanorod and a spherical DNA coated formulation resulted in toxicity. The coating material was the only factor that influenced toxicity. AuNP exposure seemed to have no effect on cell cytoskeleton deformation and cell spreading. Cell uptake, as measured by computed tomography and ICP-OES, as well as TEM images of cells, confirmed strong AuNP uptake for certain formulations, but there was no correlation with toxicity. No glove translocation occurred, therefore, nitrile gloves are an adequate safety precaution for working with the AuNP studied. In conclusion, the majority of AuNP formulations tested have very low adverse effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.