Evidence map›Paper›PMID 26031709›Full record

ArticleJournal of pain and symptom management2015

Phenotypic and Molecular Evidence Suggests That Decrements in Morning and Evening Energy Are Distinct but Related Symptoms.

Bradley E Aouizerat, Anand Dhruva, Steven M Paul, Bruce A Cooper, Kord M Kober, Christine Miaskowski

Open access · bronzeAbstract read
In one paragraph

Article in Journal of pain and symptom management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
8.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Trajectories and risk factors of fatigue following colorectal cancer diagnosis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2023
    Article
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  6. Inflamed Mind: Multiple Genetic Variants ofFrontiers in psychiatry · 2021
    Article
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  20. Age differences in fatigue, decrements in energy, and sleep disturbance in oncology patients receiving chemotherapy.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bradley E AouizeratSchool of Nursing, University of California, San Francisco, California, USA; Institute for Human Genetics, University of California, San Francisco, California, USA.
Anand DhruvaSchool of Medicine, University of California, San Francisco, California, USA.
Steven M PaulSchool of Nursing, University of California, San Francisco, California, USA.
Bruce A CooperSchool of Nursing, University of California, San Francisco, California, USA.
Kord M KoberSchool of Nursing, University of California, San Francisco, California, USA.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, California, USA. Electronic address: chris.miaskowski@ucsf.edu.
University of California, San Francisco · US

Funding

FATIGUE, PAIN, AND SLEEP PROBLEMS DURING RADIATIONR01NR004835 · NINR · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 1999 to 2002
$2.2M
A Whole Systems Approach to the Study of Ayurveda for Cancer SurvivorshipK23AT005340 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DHRUVA, ANAND · 2009 to 2013
$635k
Advancing the Science of Symptom Management in Oncology PatientsK05CA168960 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2013 to 2017
$453k
NCCIH NIH HHS K23 AT005340NCI NIH HHS K05 CA168960NINR NIH HHS NR04835NINR NIH HHS R01 NR004835
6 · The paper itself

Abstract

contextLittle is known about energy levels in oncology patients and their family caregivers.

objectivesThis study sought to identify latent classes of participants, based on self-reported energy levels and evaluate for differences in phenotypic and genotypic characteristics between these classes.

methodsEnergy subscale scores from the Lee Fatigue Scale were used to determine latent class membership. Morning and evening energy scores were obtained just before, during, and for four months after the completion of radiation therapy. Genetic associations were evaluated for 15 proinflammatory and anti-inflammatory cytokine genes.

resultsTwo latent classes with distinct morning energy trajectories were identified. Participants who were younger, female, not married/partnered, black, and had more comorbidities, and a lower functional status were more likely to be in the low morning energy class. Two polymorphisms (IL2 rs1479923 and NFKB1 rs4648110) were associated with morning energy latent class membership. Two latent classes with distinct evening energy trajectories were identified. Participants who were younger and male and who had more comorbidities, decreased body weight, and a lower functional status were more likely to be in the moderate evening energy class. Five different polymorphisms (IL1R2 rs4141134, IL6 rs4719714, IL17A rs8193036, NFKB2 rs1056890, and TNFA rs1800683) were associated with evening energy latent class membership.

conclusionThis study provides preliminary evidence that decrements in morning and evening energy are associated with different phenotypic risk factors and cytokine gene variations.

Indexed as

PhenotypePhotoperiodAgedCytokinesFatigueFemaleGenetic Association StudiesHumansLogistic ModelsLongitudinal StudiesMaleMiddle AgedNeoplasmsPolymorphism, Single NucleotideSeverity of Illness IndexCytokinescancercytokinesEnergyfamily caregiversfatiguegrowth mixture modelingradiation therapysingle nucleotide polymorphisms

Identifiers

PMID26031709
PMCPMC4624028
OpenAlexW2164361707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.