Evidence map›Paper›PMID 26031686›Full record

ArticleMicrobial ecology in health and disease2015

Opportunities to assess factors contributing to the development of the intestinal microbiota in infants living in developing countries.

Dennis Lang, MAL-ED Network Investigators

Registry-linked trialAbstract read
In one paragraph

Article in Microbial ecology in health and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03683667 (Efficacy of Supplemental Protein, Delivered Alone or in Combination With Treatment for Enteric Pathogens, to Prevent Growth Faltering in Bangladeshi Infants), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03683667 phase2 / phase3completednot on this mapstarted 2018, after this paper: background citation

Efficacy of Supplemental Protein, Delivered Alone or in Combination With Treatment for Enteric Pathogens, to Prevent Growth Faltering in Bangladeshi Infants

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2018 to 2020Enrolled5,283ConditionsStunting, Malnutrition, Protein, Enteric PathogensArmsAzithromycin Oral Product, Placebos, Protein Supplement, Isocaloric Supplement, Egg
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Long-termBio-protocol · 2018
    Article
  7. Article
  8. Review
  9. The Burden of Enteropathy and "Subclinical" Infections.Pediatric clinics of North America · 2017
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Assessing the Intestinal Microbiota in the SHINE Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015
    Article
  15. Tropical and travel-associated norovirus: current concepts.Current opinion in infectious diseases · 2015
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Dennis LangFoundation for the National Institutes of Health, Bethesda, MD, USA; Lang4@fnih.org.
MAL-ED Network Investigators
Foundation for the National Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence suggests that establishment of a healthy gut microbiota shortly after birth is important to achieve optimal growth and development of children. Being born into a resource-poor environment presents challenges to the establishment of a healthy gut microbial flora in the newborn. Among these challenges are births that occur at home, traditional pre-lacteal feeding of newborns leading to failure to initiate lactation, poor sanitation and water quality, early environmental exposure to, and infection with, enteric or other pathogens, suboptimal breast feeding duration and intensity, deficiencies in weaning and childhood diets contributing to micro- and macro-nutrient deficiencies, and the frequent use of antibiotics. These factors should be considered in the design and implementation of preventive and therapeutic interventions aimed at improving the health and development of these children.

Indexed as

child developmentdeveloping countriesenteric infectionsenvironmental enteropathygut microbiotaprobioticsunder-nutrition

Identifiers

PMID26031686
PMCPMC4451096
OpenAlexW1889122949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.