Evidence map›Paper›PMID 26031604›Full record

ArticleJournal of periodontal research2015

Differentiating zones at periodontal ligament-bone and periodontal ligament-cementum entheses.

J-H Lee, B A Pryce, R Schweitzer, M I Ryder, S P Ho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

  1. Biofabrication - Revolutionizing the future of regenerative periodontics.Dental materials : official publication of the Academy of Dental Materials · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Periodontal ligament entheses and their adaptive role in the context of dentoalveolar joint function.Dental materials : official publication of the Academy of Dental Materials · 2017
    Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

J-H LeeDivision of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California at San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8937-4011
B A PrycePortland Shriner's Research Center, Oregon Health & Science University, Portland, OR, USA.
R SchweitzerPortland Shriner's Research Center, Oregon Health & Science University, Portland, OR, USA.
M I RyderDivision of Periodontology, Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA, USA.
S P HoDivision of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California at San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USOregon Health & Science University · US

Funding

Load-mediated Adaptation of the Bone-PDL-Tooth Complex in VertebratesR01DE022032 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, SUNITA P · 2012 to 2021
$3.4M
NIDCR NIH HHS R01 DE022032
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe structural and functional integrity of bone-periodontal ligament (PDL)-cementum complex stems from the load-bearing attachment sites (entheses) between soft (PDL) and hard (bone, cementum) tissues. These attachment sites are responsible for the maintenance of a bone-PDL-cementum complex biomechanical function. The objective was to investigate changes in spatiotemporal expression of key biomolecules in developing and functionally active entheses. MATERIAL AND

methodsMultilabeling technique was performed on hemimandibles of 3 wk and 3 mo-old scleraxis-GFP transgenic mice for CD146, CD31, NG2, osterix and bone sialoprotein. Regions of dominant stretch within the PDL were evaluated by identifying directionality of collagen fibrils, PDL fibroblasts and PDL cell cytoskeleton.

resultsCD146+ cells adjacent to CD31+ vasculature were identified at PDL-bone enthesis. NG2+ cells were located at coronal bone-PDL and apical cementum-PDL entheses in the 3-wk-old group, but at 3 mo, NG2 was positive at the entheses of the apical region and alveolar crest. NG2 and osterix were colocalized at the osteoid and cementoid regions of the PDL-bone and PDL-cementum entheses. Bone sialoprotein was prominent at the apical region of 3-wk-old mice. The directionality of collagen fibers, fibroblasts and their cytoskeleton overlapped, except in the apical region of 3 wk.

conclusionColocalization of biomolecules at zones of the PDL adjacent to attachment sites may be essential for the formation of precementum and osteoid interfaces at a load-bearing bone-PDL-tooth fibrous joint. Biophysical cues resulting from development and function can regulate recruitment and differentiation of stem cells potentially from a vascular origin toward osteo- and cemento-blastic lineages at the PDL-bone and PDL-cementum entheses. Investigating the coupled effect of biophysical and biochemical stimuli leading to cell differentiation at the functional attachment sites is critical for developing regeneration strategies to enable functional reconstruction of the periodontal complex.

Indexed as

Gene Expression ProfilingAnimalsAntigensAntigens, CDBiophysical PhenomenaBone and BonesCell DifferentiationChondroitin Sulfate Proteoglycan 4Dental CementumHistocytochemistryMice, TransgenicPeriodontal LigamentProteoglycansSialoglycoproteinsSp7 Transcription FactorSpatio-Temporal AnalysisAntigensAntigens, CDChondroitin Sulfate Proteoglycan 4ProteoglycansSialoglycoproteinsSp7 protein, mouseSp7 Transcription FactorTranscription Factorsperiodontal ligamenttissue enthesestooth-bone biomechanics

Identifiers

PMID26031604
PMCPMC4663098
OpenAlexW1521142376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.