ArticleHerzschrittmachertherapie & Elektrophysiologie2015
Ventricular tachycardias in patients with pulmonary hypertension: an underestimated prevalence? A prospective clinical study.
Article in Herzschrittmachertherapie & Elektrophysiologie, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Prognostic Relevance of Nonsustained Ventricular Tachycardia in Patients with Pulmonary Hypertension.BioMed research international · 2016Trial
- Ventricular arrhythmogenesis in pulmonary hypertension: From right ventricular remodeling to clinical implications.Physiological reports · 2026Review
- Bradycardias in Patients with Pulmonary Hypertension-Prevalence, Pathophysiology and Clinical Relevance.Journal of cardiovascular development and disease · 2025Article
- Cardiac Arrhythmias in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Mechanistic Insights, Pathophysiology, and Outcomes.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024Review
- Sudden cardiac death in pulmonary arterial hypertension.International journal of cardiology. Congenital heart disease · 2024Review
- Connexin43, A Promising Target to Reduce Cardiac Arrhythmia Burden in Pulmonary Arterial Hypertension.International journal of molecular sciences · 2024Review
- In-hospital outcomes of cardiac tamponade in patients with pulmonary hypertension: A contemporary analysis.PloS one · 2024Article
- Incidence and prognostic significance of malignant arrhythmias during (repetitive) Holter electrocardiograms in patients with pulmonary hypertension.Frontiers in cardiovascular medicine · 2023Article
- The ratio of main pulmonary artery to ascending aorta diameter is associated with the right ventricular outflow tract ventriculararrhythmias.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Article
- [Tachycardia and pulmonary arterial hypertension].Herzschrittmachertherapie & Elektrophysiologie · 2020Review
- [Arrhythmias in patients with pulmonary hypertension and chronic lung disease].Herzschrittmachertherapie & Elektrophysiologie · 2019Review
- Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.Journal of molecular and cellular cardiology · 2019Article
- Arrhythmic Burden and Outcomes in Pulmonary Arterial Hypertension.Frontiers in medicine · 2019Review
- Irregular wide QRS complex tachycardia in a patient with pulmonary hypertension: What is the mechanism?HeartRhythm case reports · 2016Article
- Pathophysiology, incidence, management, and consequences of cardiac arrhythmia in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.Pulmonary circulationArticle
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSudden cardiac death (SCD) accounts for approximately 30 % in patients with pulmonary arterial hypertension (PAH). The exact circumference for SCD in this patient population is still unclear. Malignant cardiac arrhythmias are reported to be rarely present. There are no systematic data concerning long-term electrocardiographic (ECG) recording in patients with PAH.
objectivesWe sought to investigate the rate of potentially relevant arrhythmias in patients with pulmonary hypertension (PH).
methodsConsecutive patients without diagnosis of known cardiac arrhythmias followed in our outpatient clinic for PH were enrolled in the study. All patients underwent a 72-h Holter ECG. Clinical data, 6-min walk distance, laboratory values, and echocardiography were collected/performed.
resultsNinety-two consecutive patients (New York Heart Association class (NYHA) III/IV: 65.2 %/5.4 %, PH Group 1: 35.9 %, Group 3: 10.9 %, Group 4: 28.3 %, Group 5: 2.2 %) were investigated. Relevant arrhythmias were newly detected in 17 patients: non-sustained ventricular tachycardia (n = 12), intermittent second-degree heart block (n = 1), intermittent third-degree heart block (n= 3), and atrial flutter (n = 1). Echocardiographic systolic pulmonary pressure and diameter of the right heart were elevated in patients with relevant arrhythmias. Right heart catheterization revealed higher pulmonary vascular resistance (672 vs. 542 dyn · s · cm(-5), p = 0.247) and lower cardiac index (2.46 vs. 2.82 l/min/m(2), p = 0.184).
conclusionsVentricular tachycardias occur more often in PH patients than previously reported. However, the prognostic relevance of non-sustained ventricular tachycardias in this cohort remains unclear. As a large number of PH patients die from SCD, closer monitoring, e.g., using implantable event recorders, might be useful to identify patients at high risk.
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