SynthesisDigestive diseases and sciences2015
Relationship Between Cytomegalovirus Infection and Steroid Resistance in Inflammatory Bowel Disease: A Meta-Analysis.
Synthesis in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Cytomegalovirus infection and steroid-refractory inflammatory bowel disease: possible relationship from an updated meta-analysis.Irish journal of medical science · 2018Pooled it
- Immunosuppressive-Therapy Management and Day-14 Molecular Remission in Ulcerative Colitis Complicated by Cytomegalovirus Colitis: An Exploratory Prospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Cytotoxic T-Lymphocyte-Associated Protein 4 Deficiency Colitis Masked by Recurrent Cytomegalovirus Colitis Successfully Treated With Vedolizumab.ACG case reports journal · 2026Article
- Seroprevalence of CMV infection in patients with active ulcerative colitis and underlying factors of pathogenicity.BMC infectious diseases · 2025Article
- Review
- Cytomegalovirus Infection in Adult Patients with Inflammatory Bowel Disease: A Literature Review.Archives of Iranian medicine · 2024Review
- Cytomegalovirus Infection: An Underrated Target in Inflammatory Bowel Disease Treatment.Journal of clinical medicine · 2023Review
- Article
- SFED recommendations for IBD endoscopy during COVID-19 pandemic: Italian and French experience.Nature reviews. Gastroenterology & hepatology · 2020Review
- Gastroduodenal Sarcoidosis With Concomitant Cytomegalovirus Gastritis.ACG case reports journal · 2020Article
- Diagnosis and Management of CMV Colitis.Current infectious disease reports · 2019Review
- Short-Term and Long-Term Outcomes of Infliximab and Tacrolimus Treatment for Moderate to Severe Ulcerative Colitis: Retrospective Observational Study.The Kobe journal of medical sciences · 2018Observational
- CMV Infection in Pediatric IBD.Current gastroenterology reports · 2018Review
- Differential expression of serum microRNAs in glucocorticoid-resistant patients with ulcerative colitis.International journal of clinical and experimental pathology · 2018Article
- Cytomegalovirus colitis in hospitalized inflammatory bowel disease patients in Taiwan: a referral center study.BMC gastroenterology · 2017Article
- Is cytomegalovirus infection related to inflammatory bowel disease, especially steroid-resistant inflammatory bowel disease? A meta-analysis.Infection and drug resistance · 2017Article
- Serology of Viral Infections and Tuberculosis Screening in an IBD Population Referred to a Tertiary Centre of Southern Italy.Gastroenterology research and practice · 2017Article
- The silent war of CMV in aging and HIV infection.Mechanisms of ageing and development · 2016Review
- Cytomegalovirus and ulcerative colitis: Place of antiviral therapy.World journal of gastroenterology · 2016Review
- Prevalence and Risk Factors of Cytomegalovirus Colitis in Inflammatory Bowel Disease Patients in Riyadh, Saudi Arabia: A Tertiary Center Experience.Saudi journal of medicine & medical sciencesArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsSteroid resistance presents an administration difficulty in inflammatory bowel disease (IBD). The reason of steroid resistance is still unclear, but cytomegalovirus (CMV) infection may be a potential cause in some IBD patients. We carried out a meta-analysis to investigate the relationship between CMV infection and steroid-resistant IBD.
methodsThe PubMed, EMBASE, and Cochrane Library databases were searched up to June 2014, with no language restrictions, for observational studies. Additional references were obtained from reviewed articles.
resultsEleven studies involving 867 IBD patients were included in the meta-analysis. Steroid resistance rate was 70.0% in CMV-positive IBD patients, which was significantly higher than that in CMV-negative IBD patients (RR = 2.12, 95% CI = 1.72-2.61). There was significant heterogeneity in the included eleven studies (I (2) = 57.6%). When the only one study with a few patients was excluded, sensitivity analysis suggested a similar outcome (RR = 2.07, 95% CI = 1.80-2.39, 10 studies). Based on the funnel plot and Egger's test, we considered that there was a probable publication bias.
conclusionOur meta-analysis suggests that CMV-positive IBD patients have a nearly double risk of steroid resistance compared with CMV-negative IBD patients, indicating that CMV infection is a probable cause of steroid-resistant IBD.
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