ArticleDevelopment and psychopathology2016
Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings.
Article in Development and psychopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Attentional bias training in girls at risk for depression.Journal of child psychology and psychiatry, and allied disciplines · 2016Trial
- Independent, Multiplicative, and Cumulative Effects of Recent Stressful Life Events and Adverse Childhood Events on Depressive Symptoms among College Students: Moderation by the HPA-axis Multilocus Genetic Variation.Journal of youth and adolescence · 2025Article
- Reflection Rumination Reduces Negative Emotional Processing During Goal-Directed Behavior: An ERP Study.Behavioral sciences (Basel, Switzerland) · 2025Article
- Young Children of Mothers with a History of Depression Show Attention Bias to Sad Faces: An Eye-tracking Study.Research on child and adolescent psychopathology · 2024Article
- Maternal Trauma and Psychopathology Symptoms Affect Refugee Children's Mental Health But Not Their Emotion Processing.Research on child and adolescent psychopathology · 2024Article
- Biased Maintenance of Attention on Sad Faces in Clinically Depressed Youth: An Eye-Tracking Study.Child psychiatry and human development · 2023Article
- Childhood adversity and approach/avoidance-related behaviour in boys.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- An Eye-Tracking Study of Attention Biases in Children at High Familial Risk for Depression and Their Parents with Depression.Child psychiatry and human development · 2022Article
- Emotion Regulation as a Mediator in the Relationship Between Cognitive Biases and Depressive Symptoms in Depressed, At-risk and Healthy Children and Adolescents.Research on child and adolescent psychopathology · 2021Article
- The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease.International journal of molecular sciences · 2017Review
- HPA axis multilocus genetic profile score moderates the impact of interpersonal stress on prospective increases in depressive symptoms for offspring of depressed mothers.Journal of abnormal psychology · 2017Article
- Serotonin 5-HTTLPR Genotype Modulates Reactive Visual Scanning of Social and Non-social Affective Stimuli in Young Children.Frontiers in behavioral neuroscience · 2017Article
- Attentional biases to emotional stimuli: Key components of the RDoC constructs of sustained threat and loss.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- Pupillary reactivity to sad stimuli as a biomarker of depression risk: Evidence from a prospective study of children.Journal of abnormal psychology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Information-processing biases may contribute to the intergenerational transmission of depression. There is growing evidence that children of depressed mothers exhibit attentional biases for sad faces. However, findings are mixed as to whether this bias reflects preferential attention toward, versus attentional avoidance of, sad faces, suggesting the presence of unmeasured moderators. To address these mixed findings, we focused on the potential moderating role of genes associated with hypothalamic-pituitary-adrenal axis reactivity. Participants included children (8-14 years old) of mothers with (n = 81) and without (n = 81) a history of depression. Eye movements were recorded while children passively viewed arrays of angry, happy, sad, and neutral faces. DNA was obtained from buccal cells. Children of depressed mothers exhibited more sustained attention to sad faces than did children of nondepressed mothers. However, it is important that this relation was moderated by children's genotype. Specifically, children of depressed mothers who carried reactive genotypes across the corticotropin-releasing hormone type 1 receptor (CHRH1) TAT haplotype and FK506 binding protein 5 (FKBP5) rs1360780 (but not the solute carrier family C6 member 4 [SLC6A4] of the serotonin transporter linked polymorphic region [5-HTTLPR]) exhibited less sustained attention to sad faces and more sustained attention to happy faces. These findings highlight the role played by specific genetic influences and suggest that previous mixed findings may have been due to genetic heterogeneity across the samples.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.