ArticleNature neuroscience2015
Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress.
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In one paragraph
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
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70citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 2% of its field
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Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals.Cerebellum (London, England) · 2024Pooled it
- Stress-Induced Dysregulation of the Guidance Cue Receptor DCC Alters Corticolimbic Circuit Architecture.Biological psychiatry global open science · 2026Article
- Projections from ventral hippocampus to nucleus accumbens' cholinergic neurons are altered in depression.The Journal of general physiology · 2025Article
- Behavioral Animal Models and Neural-Circuit Framework of Depressive Disorder.Neuroscience bulletin · 2025Review
- A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice.Brain and behavior · 2025Article
- Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits.Biological psychiatry · 2024Article
- Neurobiological basis of stress resilience.Neuron · 2024Review
- Article
- Neural circuits regulating prosocial behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Activation of histamine type 2 receptors enhances intrinsic excitability of medium spiny neurons in the nucleus accumbens.The Journal of physiology · 2022Article
- Review
- Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches.RSC chemical biology · 2022Review
- Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner.International journal of molecular sciences · 2022Article
- Neural Circuits Underlying Social Fear in Rodents: An Integrative Computational Model.Frontiers in systems neuroscience · 2022Article
- Translating the Transcriptome: Sex Differences in the Mechanisms of Depression and Stress, Revisited.Biological psychiatry · 2022Review
- Kappa opioid receptor modulation of excitatory drive onto nucleus accumbens fast-spiking interneurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Sex and region-specific effects of variable stress on microglia morphology.Brain, behavior, & immunity - health · 2021Article
- Behavioral and accumbens synaptic plasticity induced by cues associated with restraint stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Chronic social defeat stress impairs goal-directed behavior through dysregulation of ventral hippocampal activity in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Social isolation of adolescent male rats increases anxiety and KThe European journal of neuroscience · 2021Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 4 institutions in 1 country.
Daniel J Christoffel1] Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
Sam A GoldenFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000000221042272
Jessica J Walsh1] Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Pharmacology and Systems Therapeutics, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kevin G GuiseFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mitra HeshmatiFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Allyson K FriedmanDepartment of Pharmacology and Systems Therapeutics, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Aditi DeyFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Milo SmithFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nicole RebusiFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Madeline PfauFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jessica L AblesLaboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York, USA.
Hossein AleyasinFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lena A KhibnikFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Georgia E HodesFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Gabriel A Ben-DorNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
Karl Deisseroth1] Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA. [2] Department of Bioengineering, Stanford University, Stanford, California, USA.
Matthew L ShapiroFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Robert C MalenkaNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
Ines Ibanez-TallonLaboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York, USA.
Ming-Hu Han1] Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Pharmacology and Systems Therapeutics, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Scott J RussoFishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Allen Institute for Brain Science · USStanford University · USHoward Hughes Medical Institute · USIcahn School of Medicine at Mount Sinai · US
Funding
TRANSGENIC COREP01DA008227 · NIDA · YALE UNIVERSITY · PI NESTLER, ERIC J. · 1993 to 2018
$28.1MREPRESSIVE HISTONE AND DNA METHYLATION IN RODENT DEPRESSION MODELSP50MH096890 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TAMMINGA, CAROL A · 2012 to 2021
$20.2MROLE OF PERIPHERAL IMMUNE-DERIVED MMP8 IN STRESS SUSCEPTIBILITYR01MH104559 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT JAMES RUSSO · 2014 to 2026
$9.2MPrefrontal and Medial-Temporal Interactions in MemoryP50MH094263 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MILLER, EARL K · 2011 to 2015
$8.7MInterdisciplinary Research Training in Pain and Substance Use DisordersT32DA035165 · NIDA · STANFORD UNIVERSITY · PI SEAN C MACKEY · 2013 to 2026
$7.2MProspective memory coding by the hippocampusR01MH073689 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHAPIRO, MATTHEW L · 2006 to 2022
$5.7MLearning, Prefrontal Cortex, and Multiple Memory SystemsR01MH065658 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SHAPIRO, MATTHEW L · 2002 to 2018
$5.4MResearch in Anesthesia Training Program (ReAP)T32GM089626 · NIGMS · STANFORD UNIVERSITY · PI Vivianne L Tawfik · 2010 to 2026
$5.2MRole of thalamic versus cortical inputs to nucleus accumbens in stress-related disordersR01MH090264 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2011 to 2020
$4.2MTraining Program in NeuroscienceT32MH087004 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GEORGE W. HUNTLEY · 2009 to 2026
$4.0MNeurophysiological Basis of Susceptibility and Resilience to Social Defeat StressR01MH092306 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAN, MING-HU · 2011 to 2015
$2.1MNeurophysiological Mechanisms of Variable Alcohol Drinking BehaviorsR01AA022445 · NIAAA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAN, MING-HU · 2014 to 2018
$1.7MNIAAA NIH HHS R01 AA022445NIDA NIH HHS P01 DA008227NIDA NIH HHS T32 DA035165NIGMS NIH HHS T32 GM089626NIMH NIH HHS F30 MH100835NIMH NIH HHS F31 MH105217NIMH NIH HHS F32 MH096464NIMH NIH HHS F32 MH106206NIMH NIH HHS P50 MH094263NIMH NIH HHS P50 MH096890NIMH NIH HHS R01 MH065658NIMH NIH HHS R01 MH073689NIMH NIH HHS R01 MH090264NIMH NIH HHS R01 MH092306NIMH NIH HHS R01 MH104559NIMH NIH HHS T32 MH087004NIMH NIH HHS T32 MH096678
Abstract
Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical for shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibited increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT-vSTR versus PFC-vSTR neuronal activity differentially regulated dendritic spine plasticity and social avoidance.
Indexed as
AnimalsBehavior, AnimalDendritic SpinesDisease SusceptibilityExcitatory Postsynaptic PotentialsMaleMiceMice, Inbred C57BLNeuronal PlasticityPrefrontal CortexRewardSocial BehaviorStress, PsychologicalThalamusVentral Striatum
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.