ArticlePloS one2015
Spatial heterogeneity, host movement and mosquito-borne disease transmission.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- A systematic review of dengue outbreak prediction models: Current scenario and future directions.PLoS neglected tropical diseases · 2023Pooled it
- Agent-based models of malaria transmission: a systematic review.Malaria journal · 2018Pooled it
- Landscape Heterogeneity Predicts Mosquito Vector Diversity in a Semi-arid Urbanization.EcoHealth · 2026Article
- How host mobility formulations shape estimates of pathogen dispersal and epidemic risk in non endemic regions.PLoS computational biology · 2026Article
- Mapping the local effectiveness of mass drug administration for malaria using transportability methods.Nature health · 2026Article
- The effects of variable spatial aggregation on lymphatic filariasis transmission.Parasites & vectors · 2025Article
- What Could Be Responsible for Some Mosquito-Borne Diseases? Is It Poverty, Gender Inequality, Underdevelopment, Globalization, or Climate Change? Which One(s)?Journal of tropical medicine · 2025Article
- Application of mathematical modelling to inform national malaria intervention planning in Nigeria.Malaria journal · 2023Article
- An Overview of Malaria Transmission Mechanisms, Control, and Modeling.Medical sciences (Basel, Switzerland) · 2022Review
- Host movement, transmission hot spots, and vector-borne disease dynamics on spatial networks.Infectious Disease Modelling · 2022Article
- Relating Eulerian and Lagrangian spatial models for vector-host disease dynamics through a fundamental matrix.Journal of mathematical biology · 2022Article
- Microbiota and transcriptome changes of Culex pipiens pallens larvae exposed to Bacillus thuringiensis israelensis.Scientific reports · 2021Article
- Human-Mosquito Contact: A Missing Link in Our Understanding of Mosquito-Borne Disease Transmission Dynamics.Annals of the Entomological Society of America · 2021Review
- A dynamic, ensemble learning approach to forecast dengue fever epidemic years in Brazil using weather and population susceptibility cycles.Journal of the Royal Society, Interface · 2021Article
- A Draft Genome Assembly of Culex pipiens pallens (Diptera: Culicidae) Using PacBio Sequencing.Genome biology and evolution · 2021Article
- Variation in human mobility and its impact on the risk of future COVID-19 outbreaks in Taiwan.BMC public health · 2021Article
- Migration rate estimation in an epidemic network.Applied mathematical modelling · 2021Article
- Variation in human mobility and its impact on the risk of future COVID-19 outbreaks in Taiwan.medRxiv : the preprint server for health sciences · 2020Article
- Modelling and simulating Chikungunya spread with an unstructured triangular cellular automata.Infectious Disease Modelling · 2020Article
- Local human movement patterns and land use impact exposure to zoonotic malaria in Malaysian Borneo.eLife · 2019Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mosquito-borne diseases are a global health priority disproportionately affecting low-income populations in tropical and sub-tropical countries. These pathogens live in mosquitoes and hosts that interact in spatially heterogeneous environments where hosts move between regions of varying transmission intensity. Although there is increasing interest in the implications of spatial processes for mosquito-borne disease dynamics, most of our understanding derives from models that assume spatially homogeneous transmission. Spatial variation in contact rates can influence transmission and the risk of epidemics, yet the interaction between spatial heterogeneity and movement of hosts remains relatively unexplored. Here we explore, analytically and through numerical simulations, how human mobility connects spatially heterogeneous mosquito populations, thereby influencing disease persistence (determined by the basic reproduction number R0), prevalence and their relationship. We show that, when local transmission rates are highly heterogeneous, R0 declines asymptotically as human mobility increases, but infection prevalence peaks at low to intermediate rates of movement and decreases asymptotically after this peak. Movement can reduce heterogeneity in exposure to mosquito biting. As a result, if biting intensity is high but uneven, infection prevalence increases with mobility despite reductions in R0. This increase in prevalence decreases with further increase in mobility because individuals do not spend enough time in high transmission patches, hence decreasing the number of new infections and overall prevalence. These results provide a better basis for understanding the interplay between spatial transmission heterogeneity and human mobility, and their combined influence on prevalence and R0.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.