ReviewNeurosurgical focus2015
Neurostimulation to improve level of consciousness in patients with epilepsy.
Review in Neurosurgical focus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Deep brain stimulation in pediatric dystonia: a systematic review.Neurosurgical review · 2020Pooled it
- Review
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention.NeuroImage · 2025Article
- The thalamus: Structure, function, and neurotherapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention.bioRxiv : the preprint server for biology · 2024Article
- Is there room in epilepsy for the claustrum?Frontiers in systems biology · 2024Article
- Abnormal functional connectivity of the posterior hypothalamus and other arousal regions in surgical temporal lobe epilepsy.Journal of neurosurgery · 2023Article
- Progressive generalized tonic-clonic seizures in a transgenic mouse model of adult-onset epilepsy: Implications for morphological changes in cortico-limbic and brainstem structures.Epilepsy research · 2023Article
- Identifying the neural network for neuromodulation in epilepsy through connectomics and graphs.Brain communications · 2022Article
- Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates.Scientific reports · 2021Article
- Arousal and Consciousness in Focal Seizures.Epilepsy currents · 2021Article
- Cortical low-frequency power correlates with behavioral impairment in animal model of focal limbic seizures.Epilepsia · 2021Article
- Article
- Comparison of anaesthetic- and seizure-induced states of unconsciousness: a narrative review.British journal of anaesthesia · 2021Review
- DyNeuMo Mk-2: An Investigational Circadian-Locked Neuromodulator with Responsive Stimulation for Applied Chronobiology.Conference proceedings. IEEE International Conference on Systems, Man, and Cybernetics · 2020Article
- Thalamic Stimulation Improves Postictal Cortical Arousal and Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Improving the effectiveness of ANT DBS therapy for epilepsy with optimal current targeting.Epilepsia open · 2020Article
- Sleep disruption is not observed with brain-responsive neurostimulation for epilepsy.Epilepsia open · 2020Article
- Up and Down States of Cortical Neurons in Focal Limbic Seizures.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Mechanisms of decreased cholinergic arousal in focal seizures: In vivo whole-cell recordings from the pedunculopontine tegmental nucleus.Experimental neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
When drug-resistant epilepsy is poorly localized or surgical resection is contraindicated, current neurostimulation strategies such as deep brain stimulation and vagal nerve stimulation can palliate the frequency or severity of seizures. However, despite medical and neuromodulatory therapy, a significant proportion of patients continue to experience disabling seizures that impair awareness, causing disability and risking injury or sudden unexplained death. We propose a novel strategy in which neuromodulation is used not only to reduce seizures but also to ameliorate impaired consciousness when the patient is in the ictal and postictal states. Improving or preventing alterations in level of consciousness may have an effect on morbidity (e.g., accidents, drownings, falls), risk for death, and quality of life. Recent studies may have elucidated underlying networks and mechanisms of impaired consciousness and yield potential novel targets for neuromodulation. The feasibility, benefits, and pitfalls of potential deep brain stimulation targets are illustrated in human and animal studies involving minimally conscious/vegetative states, movement disorders, depth of anesthesia, sleep-wake regulation, and epilepsy. We review evidence that viable therapeutic targets for impaired consciousness associated with seizures may be provided by key nodes of the consciousness system in the brainstem reticular activating system, hypothalamus, basal ganglia, thalamus, and basal forebrain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.