ArticlePloS one2015
Neuropsychological Correlates of Brain Perfusion SPECT in Patients with Macrophagic Myofasciitis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Aluminium adjuvants in vaccines and potential health effects: systematic review.BMJ (Clinical research ed.) · 2026Pooled it
- Causality assessment of adverse events following immunization: the problem of multifactorial pathology.F1000Research · 2020Article
- From the bluetongue vaccination campaigns in sheep to overimmunization and ovine ASIA syndrome.Immunologic research · 2018Review
- Predictive value of brain 18F-FDG PET/CT in macrophagic myofasciitis?: A case report.Medicine · 2017Article
- Article
- Prof. Shoenfeld refers to Dr. Helen Petousis-Harris' attack on Dr. Manuel Martinez-Lavin's article. Clin Rheumatol 2016; 35: 833-834.Clinical rheumatology · 2016Article
- FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis.Nuclear medicine and molecular imaging · 2016Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with aluminum hydroxide adjuvant-induced macrophagic myofasciitis (MMF) complain of arthromyalgias, chronic fatigue and cognitive deficits. This study aimed to characterize brain perfusion in these patients.
methodsBrain perfusion SPECT was performed in 76 consecutive patients (aged 49±10 y) followed in the Garches-Necker-Mondor-Hendaye reference center for rare neuromuscular diseases. Images were acquired 30 min after intravenous injection of 925 MBq 99mTc-ethylcysteinate dimer (ECD) at rest. All patients also underwent a comprehensive battery of neuropsychological tests, within 1.3±5.5 mo from SPECT. Statistical parametric maps (SPM12) were obtained for each test using linear regressions between each performance score and brain perfusion, with adjustment for age, sex, socio-cultural level and time delay between brain SPECT and neuropsychological testing.
resultsSPM analysis revealed positive correlation between neuropsychological scores (mostly exploring executive functions) and brain perfusion in the posterior associative cortex, including cuneus/precuneus/occipital lingual areas, the periventricular white matter/corpus callosum, and the cerebellum, while negative correlation was found with amygdalo-hippocampal/entorhinal complexes. A positive correlation was also observed between brain perfusion and the posterior associative cortex when the time elapsed since last vaccine injection was investigated.
conclusionsBrain perfusion SPECT showed a pattern of cortical and subcortical changes in accordance with the MMF-associated cognitive disorder previously described. These results provide a neurobiological substrate for brain dysfunction in aluminum hydroxide adjuvant-induced MMF patients.
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