ArticleOptics letters2015
Miniaturized fiber-coupled confocal fluorescence microscope with an electrowetting variable focus lens using no moving parts.
Article in Optics letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Direct laser write lithography for high optical quality electrowetting prisms.Optics express · 2024Article
- Technologies for depth scanning in miniature optical imaging systems [Invited].Biomedical optics express · 2023Review
- Two-photon microendoscope for label-free imaging in stereotactic neurosurgery.Biomedical optics express · 2023Article
- Axisymmetrical resonance modes in an electrowetting optical lens.Applied physics letters · 2023Article
- MEMS Enabled Miniature Two-Photon Microscopy for Biomedical Imaging.Micromachines · 2023Review
- A micromirror array with annular partitioning for high-speed random-access axial focusing.Light, science & applications · 2020Article
- A MEMS lens scanner based on serpentine electrothermal bimorph actuators for large axial tuning.Optics express · 2020Article
- Calibration and characteristics of an electrowetting laser scanner.IEEE sensors journal · 2020Article
- High extinction ratio, low insertion loss, optical switch based on an electrowetting prism.Optics express · 2020Article
- Converting lateral scanning into axial focusing to speed up three-dimensional microscopy.Light, science & applications · 2020Article
- Deciphering Brain Function by Miniaturized Fluorescence Microscopy in Freely Behaving Animals.Frontiers in neuroscience · 2020Review
- Using deep learning to probe the neural code for images in primary visual cortex.Journal of vision · 2019Article
- Real-Time Prosthetic Digit Actuation by Optical Read-out of Activity-Dependent Calcium Signals in an Ex Vivo Peripheral Nerve.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2019Article
- On the development of optical peripheral nerve interfaces.Neural regeneration research · 2019Review
- Lidar system with nonmechanical electrowetting-based wide-angle beam steering.Optics express · 2019Article
- Multiscale Interface Effect on Homogeneous Dielectric Structure of ZrO₂/Teflon Nanocomposite for Electrowetting Application.Polymers · 2018Article
- Three dimensional two-photon brain imaging in freely moving mice using a miniature fiber coupled microscope with active axial-scanning.Scientific reports · 2018Article
- Optical read-out and modulation of peripheral nerve activity.Neural regeneration research · 2018Review
- Numerical analysis of wavefront aberration correction using multielectrode electrowetting-based devices.Optics express · 2017Article
- Two-photon laser scanning microscopy with electrowetting-based prism scanning.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We report a miniature, lightweight fiber-coupled confocal fluorescence microscope that incorporates an electrowetting variable focus lens to provide axial scanning for full three-dimensional (3D) imaging. Lateral scanning is accomplished by coupling our device to a laser-scanning confocal microscope through a coherent imaging fiber-bundle. The optical components of the device are combined in a custom 3D-printed adapter with an assembled weight of <2 g that can be mounted onto the head of a mouse. Confocal sectioning provides an axial resolution of ∼12 μm and an axial scan range of ∼80 μm. The lateral field-of-view is 300 μm, and the lateral resolution is 1.8 μm. We determined these parameters by imaging fixed sections of mouse neuronal tissue labeled with green fluorescent protein (GFP) and fluorescent bead samples in agarose gel. To demonstrate viability for imaging intact tissue, we resolved multiple optical sections of ex vivo mouse olfactory nerve fibers expressing yellow fluorescent protein (YFP).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.