ArticleBehavioral neuroscience2015
Perirhinal cortex lesions in rats: Novelty detection and sensitivity to interference.
Article in Behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- The circuitry regulation of associative learning: dissociated and integrated function of the perirhinal cortex and hippocampus.Frontiers in neural circuits · 2026Review
- Impairment of Spatial Working Memory but Preservation of Recognition Memory in Female Rats with Spontaneous Absence Seizures.Neurochemical research · 2025Article
- Neural correlates of object identity and reward outcome in the sensory cortical-hippocampal hierarchy: coding of motivational information in perirhinal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- The Black Box effect: sensory stimulation after learning interferes with the retention of long-term object location memory in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Memory enhancing effects of nicotine, cocaine, and their conditioned stimuli; effects of beta-adrenergic and dopamine D2 receptor antagonists.Psychopharmacology · 2021Article
- Reconciling the object and spatial processing views of the perirhinal cortex through task-relevant unitization.Hippocampus · 2021Review
- The Perirhinal Cortex Engages in Area and Layer-Specific Encoding of Item Dimensions.Frontiers in behavioral neuroscience · 2021Article
- Calcineurin Signaling Mediates Disruption of the Axon Initial Segment Cytoskeleton after Injury.iScience · 2020Article
- Involvement of the Postrhinal and Perirhinal Cortices in Microscale and Macroscale Visuospatial Information Encoding.Frontiers in behavioral neuroscience · 2020Article
- Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies.Frontiers in aging neuroscience · 2020Review
- Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) regulates anxiety- and novelty-related behaviors.Genes, brain, and behavior · 2019Article
- How do memory systems detect and respond to novelty?Neuroscience letters · 2018Review
- RETRACTED: BNDF heterozygosity is associated with memory deficits and alterations in cortical and hippocampal EEG power.Behavioural brain research · 2017Article
- Medial temporal pathways for contextual learning: Network c-Brain and neuroscience advances · 2017Article
- Detecting and discriminating novel objects: The impact of perirhinal cortex disconnection on hippocampal activity patterns.Hippocampus · 2016Article
- Perirhinal cortex lesions impair tests of object recognition memory but spare novelty detection.The European journal of neuroscience · 2015Article
- Article
- Dissociating the effects of distraction and proactive interference on object memory through tests of novelty preference.Brain and neuroscience advancesArticle
- Distributed interactive brain circuits for object-in-place memory: A place for time?Brain and neuroscience advancesReview
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Rats with perirhinal cortex lesions received multiple object recognition trials within a continuous session to examine whether they show false memories. Experiment 1 focused on exploration patterns during the first object recognition test postsurgery, in which each trial contained 1 novel and 1 familiar object. The perirhinal cortex lesions reduced time spent exploring novel objects, but did not affect overall time spent exploring the test objects (novel plus familiar). Replications with subsequent cohorts of rats (Experiments 2, 3, 4.1) repeated this pattern of results. When all recognition memory data were combined (Experiments 1-4), giving totals of 44 perirhinal lesion rats and 40 surgical sham controls, the perirhinal cortex lesions caused a marginal reduction in total exploration time. That decrease in time with novel objects was often compensated by increased exploration of familiar objects. Experiment 4 also assessed the impact of proactive interference on recognition memory. Evidence emerged that prior object experience could additionally impair recognition performance in rats with perirhinal cortex lesions. Experiment 5 examined exploration levels when rats were just given pairs of novel objects to explore. Despite their perirhinal cortex lesions, exploration levels were comparable with those of control rats. While the results of Experiment 4 support the notion that perirhinal lesions can increase sensitivity to proactive interference, the overall findings question whether rats lacking a perirhinal cortex typically behave as if novel objects are familiar, that is, show false recognition. Rather, the rats retain a signal of novelty but struggle to discriminate the identity of that signal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.