ArticleScientific reports2015
Light scattering as an intrinsic indicator for pancreatic islet cell mass and secretion.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Microvascular Homeostasis Is Compromised in Pancreatic Islets in a Mouse Model of β-Cell Loss and Low-Grade Inflammation.Diabetes · 2026Article
- Longitudinal monitoring of pancreatic islet damage in streptozotocin-treated mice with optical coherence microscopy.Biomedical optics express · 2023Article
- Quantitative 3D OPT and LSFM datasets of pancreata from mice with streptozotocin-induced diabetes.Scientific data · 2022Article
- Engineering islets from stem cells for advanced therapies of diabetes.Nature reviews. Drug discovery · 2021Review
- β-Cell Pathophysiology: A Review of Advanced Optical Microscopy Applications.International journal of molecular sciences · 2021Review
- Using Organotypic Tissue Slices to Investigate the Microenvironment of Pancreatic Cancer: Pharmacotyping and Beyond.Cancers · 2021Review
- Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets.Scientific reports · 2021Article
- Mesoscopic Optical Imaging of the Pancreas-Revisiting Pancreatic Anatomy and Pathophysiology.Frontiers in endocrinology · 2021Review
- The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity.Frontiers in endocrinology · 2021Review
- Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling.eLife · 2020Article
- Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes.Communications biology · 2020Article
- Functional Characterization of the Human Islet Microvasculature Using Living Pancreas Slices.Frontiers in endocrinology · 2020Article
- Noninvasive intravital high-resolution imaging of pancreatic neuroendocrine tumours.Scientific reports · 2019Article
- Translational assessment of a genetic engineering methodology to improve islet function for transplantation.EBioMedicine · 2019Article
- In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice.Diabetologia · 2019Article
- Leader β-cells coordinate CaNature metabolism · 2019Article
- The eye as a novel imaging site in diabetes research.Pharmacology & therapeutics · 2019Review
- Local release of rapamycin by microparticles delays islet rejection within the anterior chamber of the eye.Scientific reports · 2019Article
- Diet-induced β-cell insulin resistance results in reversible loss of functional β-cell mass.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes.Scientific reports · 2017Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pancreatic islet of Langerhans is composed of endocrine cells producing and releasing hormones from secretory granules in response to various stimuli for maintenance of blood glucose homeostasis. In order to adapt to a variation in functional demands, these islets are capable of modulating their hormone secretion by increasing the number of endocrine cells as well as the functional response of individual cells. A failure in adaptive mechanisms will lead to inadequate blood glucose regulation and thereby to the development of diabetes. It is therefore necessary to develop tools for the assessment of both pancreatic islet mass and function, with the aim of understanding cellular regulatory mechanisms and factors guiding islet plasticity. Although most of the existing techniques rely on the use of artificial indicators, we present an imaging methodology based on intrinsic optical properties originating from mature insulin secretory granules within endocrine cells that reveals both pancreatic islet mass and function. We demonstrate the advantage of using this imaging strategy by monitoring in vivo scattering signal from pancreatic islets engrafted into the anterior chamber of the mouse eye, and how this versatile and noninvasive methodology permits the characterization of islet morphology and plasticity as well as hormone secretory status.
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