ReviewArchives of pathology & laboratory medicine2015
Biobanking in genomic medicine.
Review in Archives of pathology & laboratory medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Optimizing Tissue Sampling Timing for Accurate Gene Expression Analysis.International journal of molecular sciences · 2025Article
- Enhancing preanalytic surgical specimen management: experience of a system implementation initiative.Diagnostic pathology · 2025Article
- Deep silicification-assisted long-term preservation of structural and genomic information across biospecies: From micro to macro.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Advancing wide implementation of precision oncology: A liquid nitrogen-free snap freezer preserves molecular profiles of biological samples.Cancer medicine · 2023Article
- The biobank of barretos cancer hospital: 14 years of experience in cancer research.Cell and tissue banking · 2022Article
- A high-throughput real-time PCR tissue-of-origin test to distinguish blood from lymphoblastoid cell line DNA for (epi)genomic studies.Scientific reports · 2022Article
- Microbial occurrence in liquid nitrogen storage tanks: a challenge for cryobanking?Applied microbiology and biotechnology · 2021Review
- Effects of ex vivo ischemia time and delayed processing on quality of specimens in tissue biobank.Molecular medicine reports · 2020Article
- Pathology and Biobanking.Turk patoloji dergisi · 2020Review
- Specimen Collection for Translational Studies in Hidradenitis Suppurativa.Scientific reports · 2019Article
- Mechanisms and Measurement of Changes in Gene Expression.Biological research for nursing · 2018Article
- [Biobanking and the further development of precision medicine].Der Pathologe · 2018Review
- Ensuring the Safety and Security of Frozen Lung Cancer Tissue Collections through the Encapsulation of Dried DNA.Cancers · 2018Article
- Tumor Pre-Analytics in Molecular Pathology: Impact on Protein Expression and Analysis.Current pathobiology reports · 2018Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
contextGenomic medicine requires the identification of biomarkers and therapeutic targets, which in turn, requires high-quality biospecimens. Achieving high-quality biospecimens requires implementing standard operating procedures to control the variations of preanalytic variables in biobanking. Currently, most biobanks do not control the variations of preanalytic variables when collecting, processing, and storing their biospecimens. However, those variations have been shown to affect the quality of biospecimens and gene expression profiling.
objectiveTo identify evidence-based preanalytic parameters that can be applied and those parameters that need further study. DATA SOURCES: We searched the Biospecimen Research and PubMed databases using defined key words. We retrieved and reviewed 212 articles obtained through those searches. We included 58 articles (27%) according to our inclusion and exclusion criteria for this review.
conclusion-Preanalytic variables in biobanking can degrade the quality of biospecimens and alter gene expression profiling. Variables that require further study include the effect of surgical manipulation; the effect of warm ischemia; the allowable duration of delayed specimen processing; the optimal type, duration, and temperature of preservation and fixation; and the optimal storage duration of formalin-fixed, paraffin embedded specimens in a fit-for-purpose approach.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.