ArticlePloS one2015
Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy.
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In one paragraph
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Genetic and nongenetic factors affecting vancomycin population pharmacokinetics and pharmacodynamics: A systematic review.Indian journal of pharmacology · 2026Pooled it
- Evaluation of Vancomycin Therapeutic Drug Monitoring Strategies: Pharmacokinetic, Pharmacogenetic, and Clinical Perspectives in a Prospective, Real-World Cohort Study.European journal of clinical pharmacology · 2026Article
- Anti-Infective-Associated AKI: A Narrative Review of the Epidemiology, Mechanisms, Risk Factors, Biomarkers, Clinical Course, Monitoring, Prevention, and Therapeutic Strategies.Antibiotics (Basel, Switzerland) · 2025Review
- Optimizing vancomycin dosing in pediatrics: a machine learning approach to predict trough concentrations in children under four years of age.International journal of clinical pharmacy · 2024Observational
- Analysis Approaches to Identify Pharmacogenetic Associations With Pharmacodynamics.Clinical pharmacology and therapeutics · 2021Review
- Pharmacogenomics of Antibiotics.International journal of molecular sciences · 2020Review
- Identification of Novel Biomarkers for Predicting Kidney Injury Due to Drugs Using "Omic" Strategies.Pharmacogenomics and personalized medicine · 2020Review
- Exome-Based Rare-Variant Analyses in CKD.Journal of the American Society of Nephrology : JASN · 2019Article
- PGxO and PGxLOD: a reconciliation of pharmacogenomic knowledge of various provenances, enabling further comparison.BMC bioinformatics · 2019Article
- The Influence of Big (Clinical) Data and Genomics on Precision Medicine and Drug Development.Clinical pharmacology and therapeutics · 2018Article
- Genome-wide and Phenome-wide Approaches to Understand Variable Drug Actions in Electronic Health Records.Clinical and translational science · 2018Review
- Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission.Journal of medical virology · 2018Article
- A comparative study of different methods for automatic identification of clopidogrel-induced bleedings in electronic health records.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2017Article
- Phenome-Wide Association Studies as a Tool to Advance Precision Medicine.Annual review of genomics and human genetics · 2016Review
- Clinical phenotyping in selected national networks: demonstrating the need for high-throughput, portable, and computational methods.Artificial intelligence in medicine · 2016Article
- Integrating electronic health record genotype and phenotype datasets to transform patient care.Clinical pharmacology and therapeutics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 6 institutions in 1 country.
Sara L Van DriestDepartment of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, United States of America.
Tracy L McGregorDepartment of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, United States of America; Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America.
Digna R Velez EdwardsCenter for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, Tennessee, United States of America.
Ben R SavilleDepartment of Biostatistics, Vanderbilt University, Nashville, Tennessee, United States of America.
Terrie E KitchnerCenter for Human Genetics, Marshfield Clinic, Marshfield, Wisconsin, United States of America.
Scott J HebbringCenter for Human Genetics, Marshfield Clinic, Marshfield, Wisconsin, United States of America.
Murray BrilliantCenter for Human Genetics, Marshfield Clinic, Marshfield, Wisconsin, United States of America.
Hayan JouniDivision of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Iftikhar J KulloDivision of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
C Buddy CreechDepartment of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, United States of America.
Prince J KannankerilDepartment of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, United States of America.
Susan I VearDepartment of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, United States of America.
Kyle B BrothersDepartment of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, United States of America.
Erica A BowtonInstitute for Clinical and Translational Research, Vanderbilt University, Nashville, Tennessee, United States of America.
Christian M ShafferDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America.
Neelam PatelSchool of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.
Jessica T DelaneyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Yuki BradfordCenter for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America.
Sarah WilsonCenter for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America.
Lana M OlsonCenter for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America.
Dana C CrawfordCenter for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America.
Amy L PottsDepartment of Pharmaceutical Services, Vanderbilt University, Nashville, Tennessee, United States of America.
Richard H HoDepartment of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, United States of America.
Dan M RodenDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Josh C DennyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America; Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, United States of America.
Vanderbilt University · USCenter for Human Genetics · USMarshfield Clinic · USMayo Clinic · USMonroe Carell Jr. Children's Hospital · USVanderbilt University Medical Center · US
Funding
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MInstitutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2MGenomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5MCLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM007569 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bjorn C Knollmann · 1985 to 2026
$12.4MBuilding Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3MVanderbilt Genome-Electronic Records ProjectU01HG004603 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2007 to 2011
$7.3MVESPA: Vanderbilt Electronic Systems for Pharmacogenomic AssessmentRC2GM092618 · NIGMS · VANDERBILT UNIVERSITY · PI DENNY, JOSHUA C., RODEN, DAN M · 2009 to 2010
$6.4MIRIS: Incorporating Research Into SightU01HG006389 · NHGRI · ESSENTIA INSTITUTE OF RURAL HEALTH · PI MCCARTY, CATHERINE ANNE · 2011 to 2014
$4.1MVanderbilt Genome Electronic Records ProjectU01HG006378 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2011 to 2014
$4.0MEMR Phenotypes and Community Engaged Genomic AssociationsU01HG004599 · NHGRI · MAYO CLINIC ROCHESTER · PI CHUTE, CHRISTOPHER G · 2007 to 2010
$3.7MVanderbilt Environmental Health Science Scholars ProgramK12ES015855 · NIEHS · VANDERBILT UNIVERSITY · PI BROWN, NANCY J. · 2007 to 2011
$3.5MNCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1-TR000427NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1-TR000445NCRR NIH HHS UL1 RR024975NCRR NIH HHS UL1-RR024975NHGRI NIH HHS 1U01-HG006389NHGRI NIH HHS U01 HG004599NHGRI NIH HHS U01 HG004603NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01-HG006379NHGRI NIH HHS U01 HG006389NHGRI NIH HHS U01-HG04599NHGRI NIH HHS U01-HG04603NICHD NIH HHS 1K23-HD000001NICHD NIH HHS 2K12-HD043483-11NICHD NIH HHS K12 HD043483NICHD NIH HHS K23 HD000001NIEHS NIH HHS K12 ES015855NIEHS NIH HHS K12-ES015855NIGMS NIH HHS 5T32-GM007569NIGMS NIH HHS RC2 GM092618NIGMS NIH HHS RC2-GM092618NIGMS NIH HHS T32 GM007569
Abstract
Vancomycin, a commonly used antibiotic, can be nephrotoxic. Known risk factors such as age, creatinine clearance, vancomycin dose / dosing interval, and concurrent nephrotoxic medications fail to accurately predict nephrotoxicity. To identify potential genomic risk factors, we performed a genome-wide association study (GWAS) of serum creatinine levels while on vancomycin in 489 European American individuals and validated findings in three independent cohorts totaling 439 European American individuals. In primary analyses, the chromosome 6q22.31 locus was associated with increased serum creatinine levels while on vancomycin therapy (most significant variant rs2789047, risk allele A, β = -0.06, p = 1.1 x 10(-7)). SNPs in this region had consistent directions of effect in the validation cohorts, with a meta-p of 1.1 x 10(-7). Variation in this region on chromosome 6, which includes the genes TBC1D32/C6orf170 and GJA1 (encoding connexin43), may modulate risk of vancomycin-induced kidney injury.
Indexed as
Adaptor Proteins, Signal TransducingAdultAgedChromosomes, HumanChromosomes, Human, Pair 6Connexin 43CreatinineFemaleGenome-Wide Association StudyGenotypeGTPase-Activating ProteinsHumansMaleMiddle AgedPolymorphism, Single NucleotideVancomycinAdaptor Proteins, Signal TransducingConnexin 43CreatinineGJA1 protein, humanGTPase-Activating ProteinsTBC1D32 protein, humanVancomycin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.