ArticlePloS one2015
The impact of stannous, fluoride ions and its combination on enamel pellicle proteome and dental erosion prevention.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
- Plant extracts have dual mechanism on the protection against dentine erosion: action on the dentine substrate and modification of the salivary pellicle.Scientific reports · 2023Trial
- Trial
- Is the dentifrice containing calcium silicate, sodium phosphate, and fluoride able to protect enamel against chemical mechanical wear? An in situ/ex vivo study.Clinical oral investigations · 2019Trial
- Trial
- In situ effect of enamel salivary exposure time and type of intraoral appliance before an erosive challenge.Clinical oral investigations · 2017Trial
- Influence of Slurry Diluents on Toothpaste Efficacy Against Erosive Tooth Wear: In Vitro and In Situ Studies.Brazilian dental journal · 2025Article
- Synergistic effect of Maquiberry cystatin, sodium fluoride and stannous chloride for the prevention of initial dental erosion in vitro.Journal of applied oral science : revista FOB · 2025Article
- Effect of pellicle modification with polyphenol-rich solutions on enamel erosion and abrasion.Brazilian oral research · 2025Article
- Starch treatment improves the salivary proteome for subject identification purposes.Forensic science, medicine, and pathology · 2024Article
- Impact of pH-adjusted fluoride and stannous solutions on the protective properties on the pellicle layer in vitro and in situ.Scientific reports · 2024Article
- Combined use of stannous fluoride-containing mouth rinse and toothpaste prevents enamel erosion in vitro.Clinical oral investigations · 2023Article
- Caries Management-The Role of Surface Interactions in De- and Remineralization-Processes.Journal of clinical medicine · 2022Review
- Synergistic effect between plant extracts and fluoride to protect against enamel erosion: An in vitro study.PloS one · 2022Article
- Revisiting Fluoride in the Twenty-First Century: Safety and Efficacy Considerations.Frontiers in oral health · 2022Article
- Efficacy of mouthrinses with bovine milk and milk protein isolates to accumulate casein in the in situ pellicle.Clinical oral investigations · 2020Article
- Mineral Trioxide Aggregate Applications in Endodontics: A Review.European journal of dentistry · 2020Article
- Effect ofJournal of clinical and experimental dentistry · 2020Article
- Influence of pure fluorides and stannous ions on the initial bacterial colonization in situ.Scientific reports · 2019Article
- Effect of fluoride mouthrinses and stannous ions on the erosion protective properties of the in situ pellicle.Scientific reports · 2019Article
- Novel methodology for determining the effect of adsorbates on human enamel acid dissolution.Archives of oral biology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo compare the effects of stannous (Sn) and fluoride (F) ions and their combination on acquired enamel pellicle (AEP) protein composition (proteome experiment), and protection against dental erosion (functional experiment).
methodsIn the proteome experiment, bovine enamel specimens were incubated in whole saliva supernatant for 24h for AEP formation. They were randomly assigned to 4 groups (n=10), according to the rinse treatment: Sn (800ppm/6.7mM, SnCl2), F (225ppm/13mM, NaF), Sn and F combination (Sn+F) and deionized water (DIW, negative control). The specimens were immersed 3× in the test rinses for 2min, 2h apart. Pellicles were collected, digested, and analyzed for protein content using liquid chromatography electrospray ionization tandem mass spectrometry. In the functional experiment, bovine enamel specimens (n=10) were similarly treated for pellicle formation. Then, they were subjected to a five-day erosion cycling model, consisting of 5min erosive challenges (15.6 mM citric acid, pH 2.6, 6×/d) and 2min treatment with the rinses containing Sn, F or Sn+F (3×/d). Between the treatments, all specimens were incubated in whole saliva supernatant. Surface loss was determined by profilometry.
resultsOur proteome approach on bovine enamel identified 72 proteins that were common to all groups. AEP of enamel treated with Sn+F demonstrated higher abundance for most of the identified proteins than the other groups. The functional experiment showed reduction of enamel surface loss for Sn+F (89%), Sn (67%) and F (42%) compared to DIW (all significantly different, p<0.05).
conclusionThis study highlighted that anti-erosion rinses (e.g. Sn+F) can modify quantitatively and qualitatively the AEP formed on bovine enamel. Moreover, our study demonstrated a combinatory effect that amplified the anti-erosive protection on tooth surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.