ArticleInvestigative ophthalmology & visual science2015
Adaptability of the Immature Ocular Motor Control System: Unilateral IGF-1 Medial Rectus Treatment.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 17 citations in OpenAlex.
- Effects of Short-Term Treatment of Rabbit Extraocular Muscle With Ciliary Neurotrophic Factor.Investigative ophthalmology & visual science · 2024Article
- Alteration of Neurotrophic Factors and Innervation in Extraocular Muscles of Individuals With Concomitant Esotropia.Investigative ophthalmology & visual science · 2024Article
- Association ofMolecular vision · 2022Article
- Effect of Fibroblast Growth Factor 2 on Extraocular Muscle Structure and Function.Investigative ophthalmology & visual science · 2021Article
- Eye alignment changes caused by sustained GDNF treatment of an extraocular muscle in infant non-human primates.Scientific reports · 2020Article
- Visualizing Neuronal Adaptation Over Time After Treatment of Strabismus.Investigative ophthalmology & visual science · 2018Article
- Changing muscle function with sustained glial derived neurotrophic factor treatment of rabbit extraocular muscle.PloS one · 2018Article
- Nonhuman Primate Studies to Advance Vision Science and Prevent Blindness.ILAR journal · 2017Review
- Neural mechanisms of oculomotor abnormalities in the infantile strabismus syndrome.Journal of neurophysiology · 2017Review
- Improvement of Eye Alignment in Adult Strabismic Monkeys by Sustained IGF-1 Treatment.Investigative ophthalmology & visual science · 2016Article
- Strabismus and the Oculomotor System: Insights from Macaque Models.Annual review of vision science · 2016Article
- Prolongation of Relaxation Time in Extraocular Muscles With Brain Derived Neurotrophic Factor in Adult Rabbit.Investigative ophthalmology & visual science · 2016Article
- Altered Protein Composition and Gene Expression in Strabismic Human Extraocular Muscles and Tendons.Investigative ophthalmology & visual science · 2016Article
- Review
- Adaptation of slow myofibers: the effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates.Investigative ophthalmology & visual science · 2015Article
- Childhood Onset Strabismus: A Neurotrophic Factor Hypothesis.Journal of binocular vision and ocular motilityArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeUnilateral treatment with sustained release IGF-1 to one medial rectus muscle in infant monkeys was performed to test the hypothesis that strabismus would develop as a result of changes in extraocular muscles during the critical period of development of binocularity.
methodsSustained release IGF-1 pellets were implanted unilaterally on one medial rectus muscle in normal infant monkeys during the first 2 weeks of life. Eye position was monitored using standard photographic methods. After 3 months of treatment, myofiber and neuromuscular size, myosin composition, and innervation density were quantified in all rectus muscles and compared to those in age-matched controls.
resultsSustained unilateral IGF-1 treatments resulted in strabismus for all treated subjects; 3 of the 4 subjects had a clinically significant strabismus of more than 10°. Both the treated medial rectus and the untreated ipsilateral antagonist lateral rectus muscles had significantly larger myofibers. No adaptation in myofiber size occurred in the contralateral functionally yoked lateral rectus or in myosin composition, neuromuscular junction size, or nerve density.
conclusionsSustained unilateral IGF-1 treatment to extraocular muscles during the sensitive period of development of orthotropic eye alignment and binocularity was sufficient to disturb ocular motor development, resulting in strabismus in infant monkeys. This could be due to altering fusion of gaze during the early sensitive period. Serial measurements of eye alignment suggested the IGF-1-treated infants received insufficient coordinated binocular experience, preventing the establishment of normal eye alignment. Our results uniquely suggest that abnormal signaling by the extraocular muscles may be a cause of strabismus.
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