ArticleInvestigative ophthalmology & visual science2015
Adaptation of slow myofibers: the effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Cytoprotective Compounds in the Primate Eye: Baseline Metabolomic Profiles ofInternational journal of molecular sciences · 2025Article
- Extreme Tolerance of Extraocular Muscles to Diseases and Aging: Why and How?International journal of molecular sciences · 2024Review
- Alteration of Neurotrophic Factors and Innervation in Extraocular Muscles of Individuals With Concomitant Esotropia.Investigative ophthalmology & visual science · 2024Article
- Brain-derived Neurotrophic Factor and Its Applications through Nanosystem Delivery.Iranian journal of pharmaceutical research : IJPR · 2021Review
- Effect of high-BDNF microenvironment stem cells therapy on neurogenic bladder model in rats.Translational andrology and urology · 2021Article
- Eye alignment changes caused by sustained GDNF treatment of an extraocular muscle in infant non-human primates.Scientific reports · 2020Article
- Changing muscle function with sustained glial derived neurotrophic factor treatment of rabbit extraocular muscle.PloS one · 2018Article
- Nonhuman Primate Studies to Advance Vision Science and Prevent Blindness.ILAR journal · 2017Review
- Extraocular Muscle Repair and Regeneration.Current ophthalmology reports · 2017Article
- Neural mechanisms of oculomotor abnormalities in the infantile strabismus syndrome.Journal of neurophysiology · 2017Review
- Article
- Prolongation of Relaxation Time in Extraocular Muscles With Brain Derived Neurotrophic Factor in Adult Rabbit.Investigative ophthalmology & visual science · 2016Article
- Altered Protein Composition and Gene Expression in Strabismic Human Extraocular Muscles and Tendons.Investigative ophthalmology & visual science · 2016Article
- Abnormally Small Neuromuscular Junctions in the Extraocular Muscles From Subjects With Idiopathic Nystagmus and Nystagmus Associated With Albinism.Investigative ophthalmology & visual science · 2016Article
- Review
- Childhood Onset Strabismus: A Neurotrophic Factor Hypothesis.Journal of binocular vision and ocular motilityArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWe evaluated promising new treatment options for strabismus. Neurotrophic factors have emerged as a potential treatment for oculomotor disorders because of diverse roles in signaling to muscles and motor neurons. Unilateral treatment with sustained release brain-derived neurotrophic factor (BDNF) to a single lateral rectus muscle in infant monkeys was performed to test the hypothesis that strabismus would develop in correlation with extraocular muscle (EOM) changes during the critical period for development of binocularity.
methodsThe lateral rectus muscles of one eye in two infant macaques were treated with sustained delivery of BDNF for 3 months. Eye alignment was assessed using standard photographic methods. Muscle specimens were analyzed to examine the effects of BDNF on the density, morphology, and size of neuromuscular junctions, as well as myofiber size. Counts were compared to age-matched controls.
resultsNo change in eye alignment occurred with BDNF treatment. Compared to control muscle, neuromuscular junctions on myofibers expressing slow myosins had a larger area. Myofibers expressing slow myosin had larger diameters, and the percentage of myofibers expressing slow myosins increased in the proximal end of the muscle. Expression of BDNF was examined in control EOM, and observed to have strongest immunoreactivity outside the endplate zone.
conclusionsWe hypothesize that the oculomotor system adapted to sustained BDNF treatment to preserve normal alignment. Our results suggest that BDNF treatment preferentially altered myofibers expressing slow myosins. This implicates BDNF signaling as influencing the slow twitch properties of EOM.
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