Evidence map›Paper›PMID 26030009›Full record

ArticleScientific reports2015

Automated pipeline for purification, biophysical and x-ray analysis of biomacromolecular solutions.

Melissa A Graewert, Daniel Franke, Cy M Jeffries, Clement E Blanchet, Darja Ruskule, Katja Kuhle, Antje Flieger, Bernd Schäfer, Bernd Tartsch, Rob Meijers and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 112 citations in OpenAlex.

  1. Review
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  5. Review
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  11. Review
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  17. Journal of applied crystallography · 2021
    Article
  18. Article
  19. Article
  20. Domain Organization in Plant Blue-Light Receptor Phototropin2 ofInternational journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Melissa A GraewertEuropean Molecular Biology Laboratory (EMBL) Hamburg, 22607 Hamburg, Germany.
Daniel FrankeEuropean Molecular Biology Laboratory (EMBL) Hamburg, 22607 Hamburg, Germany.
Cy M JeffriesEuropean Molecular Biology Laboratory (EMBL) Hamburg, 22607 Hamburg, Germany.
Clement E BlanchetEuropean Molecular Biology Laboratory (EMBL) Hamburg, 22607 Hamburg, Germany.
Darja RuskuleEuropean Molecular Biology Laboratory (EMBL) Hamburg, 22607 Hamburg, Germany.
Katja KuhleRobert Koch-Institut, Division of Enteropathogenic Bacteria and Legionella (FG11), Burgstr. 37, 38855 Wernigerode, Germany.
Antje FliegerRobert Koch-Institut, Division of Enteropathogenic Bacteria and Legionella (FG11), Burgstr. 37, 38855 Wernigerode, Germany.
Bernd SchäferMalvern Instruments GmbH, Rigipsstr. 19, 71083 Herrenberg, Germany.
Bernd TartschMalvern Instruments GmbH, Rigipsstr. 19, 71083 Herrenberg, Germany.
Rob MeijersEuropean Molecular Biology Laboratory (EMBL) Hamburg, 22607 Hamburg, Germany.
Dmitri I SvergunEuropean Molecular Biology Laboratory (EMBL) Hamburg, 22607 Hamburg, Germany.
European Molecular Biology Laboratory · DERobert Koch Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small angle X-ray scattering (SAXS), an increasingly popular method for structural analysis of biological macromolecules in solution, is often hampered by inherent sample polydispersity. We developed an all-in-one system combining in-line sample component separation with parallel biophysical and SAXS characterization of the separated components. The system coupled to an automated data analysis pipeline provides a novel tool to study difficult samples at the P12 synchrotron beamline (PETRA-3, EMBL/DESY, Hamburg).

Indexed as

BiophysicsMacromolecular SubstancesScattering, Small AngleSolutionsMacromolecular SubstancesSolutions

Identifiers

PMID26030009
PMCPMC5377070
OpenAlexW1695820403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.