Evidence map›Paper›PMID 26029921›Full record

Trial reportPloS one2015

Quality of Life after Diet or Exercise-Induced Weight Loss in Overweight to Obese Postmenopausal Women: The SHAPE-2 Randomised Controlled Trial.

Willemijn A M van Gemert, Job van der Palen, Evelyn M Monninkhof, Anouk Rozeboom, Roelof Peters, Harriet Wittink, Albertine J Schuit, Petra H Peeters

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01511276 (The Effects of Equivalent Weight Loss With or Without Exercise Training on Breast Cancer Risk Biomarkers in Postmenopausal Women), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01511276 nacompletednot on this map

The Effects of Equivalent Weight Loss With or Without Exercise Training on Breast Cancer Risk Biomarkers in Postmenopausal Women: the SHAPE-2 Study

TypeinterventionalSponsorUMC UtrechtRan2012 to 2014Enrolled243ConditionsBreast Cancer RiskArmsDiet, Mainly exercise induced weight loss
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  9. Disentangling direct and weight-mediated effects of physical activity on health-related quality of life in a 12-month real-world digital lifestyle intervention.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
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  19. Nutritional Determinants of Quality of Life in a Mediterranean Cohort: The SUN Study.International journal of environmental research and public health · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Willemijn A M van GemertUniversity Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, department of epidemiology, P.O. Box 85500, 3508 GA, Utrecht, the Netherlands.
Job van der PalenMedisch Spectrum Twente Hospital, Department of Epidemiology, P.O. Box 50000, 7500 KA, Enschede, the Netherlands; University of Twente, Department of Research Methodology, Measurement, and Data Analysis, P.O. Box 217, 7500 AE, Enschede, the Netherlands.
Evelyn M MonninkhofUniversity Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, department of epidemiology, P.O. Box 85500, 3508 GA, Utrecht, the Netherlands.
Anouk RozeboomUniversity Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, department of epidemiology, P.O. Box 85500, 3508 GA, Utrecht, the Netherlands.
Roelof PetersUtrecht University of Applied Sciences, Research group Lifestyle and Health, Faculty of Health Care, P.O. Box 85182, 3508 AD, Utrecht, the Netherlands.
Harriet WittinkUtrecht University of Applied Sciences, Research group Lifestyle and Health, Faculty of Health Care, P.O. Box 85182, 3508 AD, Utrecht, the Netherlands.
Albertine J SchuitNational Institute for Public Health and the Environment, Division of Public Health and Health Care, P.O. Box 1, 3720 BA, Bilthoven, the Netherlands; VU University, Department of Health Sciences and EMGO Institute for Health and Care Research, Van der Boechorststraat 7, 1081 BT, Amsterdam, the Netherlands.
Petra H PeetersUniversity Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, department of epidemiology, P.O. Box 85500, 3508 GA, Utrecht, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study investigates the effect of a modest weight loss either by a calorie restricted diet or mainly by increased physical exercise on health related quality of life (HRQoL) in overweight-to-obese and inactive postmenopausal women. We hypothesize that HRQoL improves with weight loss, and that exercise-induced weight loss is more effective for this than diet-induced weight loss.

methodsThe SHAPE-2 trial was primarily designed to evaluate any additional effect of weight loss by exercise compared with a comparable amount of weight loss by diet on biomarkers relevant for breast cancer risk. In the present analysis we focus on HRQoL. We randomly assigned 243 eligible women to a diet (n = 97), exercise (n = 98), or control group (n = 48). Both interventions aimed for 5-6 kg weight loss. HRQoL was measured at baseline and after 16 weeks by the SF-36 questionnaire.

resultsData of 214 women were available for analysis. Weight loss was 4.9 kg (6.1%) and 5.5 kg (6.9%) with diet and exercise, respectively. Scores of the SF-36 domain 'health change' increased significantly by 8.8 points (95% CI 1.6;16.1) with diet, and by 20.5 points (95% CI 13.2;27.7) with exercise when compared with control. Direct comparison of diet and exercise showed a statistically significantly stronger improvement with exercise. Both intervention groups showed a tendency towards improvements in most other domains, which were more pronounced in the exercise group, but not statistically different from control or each other.

conclusionIn a randomized trial in overweight-to-obese and inactive postmenopausal women a comparable 6%-7% weight loss was achieved by diet-only or mainly by exercise and showed improvements in physical and mental HRQoL domains, but results were not statistically significant in either the diet or exercise group. However, a modest weight loss does lead to a positive change in self-perceived health status. This effect was significantly larger with exercise-induced weight loss than with comparable diet-induced weight loss.

trial registrationClinicalTrials.gov NCT01511276.

Indexed as

PostmenopauseBiomarkersDietExerciseFemaleHumansMaleMiddle AgedObesityOverweightQuality of LifeWeight LossBiomarkers

Identifiers

PMID26029921
PMCPMC4452367

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.