ArticlePloS one2015
Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by time domain diffuse optical spectroscopy.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Intra-individual Gene Expression Variability of Histologically Normal Breast Tissue.Scientific reports · 2018Trial
- Monitoring of neoadjuvant chemotherapy through time domain diffuse optics: breast tissue composition changes and collagen discriminative potential.Biomedical optics express · 2024Article
- Breast Cancer Diagnosis Using Extended-Wavelength-Diffuse Reflectance Spectroscopy (EW-DRS)-Proof of Concept in Ex Vivo Breast Specimens Using Machine Learning.Diagnostics (Basel, Switzerland) · 2023Article
- Customizable optical tissue phantom platform for characterization of fluorescence imaging device sensitivity.Journal of biomedical optics · 2023Article
- A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.Nature communications · 2023Article
- Alternative methods to measure breast density in younger women.British journal of cancer · 2023Article
- Childhood adiposity, serum metabolites and breast density in young women.Breast cancer research : BCR · 2022Article
- Non-invasive monitoring of blood oxygenation in human placentas via concurrent diffuse optical spectroscopy and ultrasound imaging.Nature biomedical engineering · 2022Article
- A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women.Scientific reports · 2022Article
- Irradiated Triple-Negative Breast Cancer Co-Culture Produces a Less Oncogenic Extracellular Matrix.International journal of molecular sciences · 2022Article
- Photoacoustic imaging phantoms for assessment of object detectability and boundary buildup artifacts.Photoacoustics · 2022Article
- Tissue-mimicking phantom materials with tunable optical properties suitable for assessment of diffuse reflectance spectroscopy during electrosurgery.Biomedical optics express · 2022Article
- Breast cancer diagnosis using frequency decomposition of surface motion of actuated breast tissue.Frontiers in oncology · 2022Article
- Suite of 3D test objects for performance assessment of hybrid photoacoustic-ultrasound breast imaging systems.Journal of biomedical optics · 2021Article
- Broadband diffuse optical spectroscopy of absolute methemoglobin concentration can distinguish benign and malignant breast lesions.Journal of biomedical optics · 2021Article
- Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity.PLoS computational biology · 2020Article
- Semi-anthropomorphic photoacoustic breast phantom.Biomedical optics express · 2019Article
- Characterization and modeling of acousto-optic signal strengths in highly scattering media.Biomedical optics express · 2019Article
- Diffuse optical tomography of the breast: a potential modifiable biomarker of breast cancer risk with neoadjuvant chemotherapy.Biomedical optics express · 2019Article
- Emerging Breast Imaging Technologies on the Horizon.Seminars in ultrasound, CT, and MR · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast tissue composition is recognized as a strong and independent risk factor for breast cancer. It is a heritable feature, but is also significantly affected by several other elements (e.g., age, menopause). Nowadays it is quantified by mammographic density, thus requiring the use of ionizing radiation. Optical techniques are absolutely non-invasive and have already proved effective in the investigation of biological tissues, as they are sensitive to tissue composition and structure.
methodsTime domain diffuse optical spectroscopy was performed at 7 wavelengths (635-1060 nm) on 200 subjects to derive their breast tissue composition (in terms of water, lipid and collagen content), blood parameters (total hemoglobin content and oxygen saturation level), and information on the microscopic structure (scattering amplitude and power). The dependence of all optically-derived parameters on age, menopausal status, body mass index, and use of oral contraceptives, and the correlation with mammographic density were investigated.
resultsYounger age, premenopausal status, lower body mass index values, and use of oral contraceptives all correspond to significantly higher water, collagen and total hemoglobin content, and lower lipid content (always p < 0.05 and often p < 10-4), while oxygen saturation level and scattering parameters show significant dependence only on some conditions. Even when age-adjusted groups of subjects are compared, several optically derived parameters (and in particular always collagen and total hemoglobin content) remain significantly different.
conclusionsTime domain diffuse optical spectroscopy can probe non-invasively breast tissue composition and physiologic blood parameters, and provide information on tissue structure. The measurement is suitable for in vivo studies and monitoring of changes in breast tissue (e.g., with age, lifestyle, chemotherapy, etc.) and to gain insight into related processes, like the origin of cancer risk associated with breast density.
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