ArticleNature genetics2015
Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma.
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Article in Nature genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 50 citations in OpenAlex.
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- Multiomics Approach to Acromegaly: Unveiling Translational Insights for Precision Medicine.Endocrinology and metabolism (Seoul, Korea) · 2023Review
- Major Genetic Motifs in Pituitary Adenomas: A Practical Literature Update.World neurosurgery · 2023Review
- Clinical Biology of the Pituitary Adenoma.Endocrine reviews · 2022Review
- A Common Variant in theInternational journal of molecular sciences · 2022Article
- Genetic and Epigenetic Pathogenesis of Acromegaly.Cancers · 2022Review
- Transcription factor GTF2B regulates AIP protein expression in growth hormone-secreting pituitary adenomas and influences tumor phenotypes.Neuro-oncology · 2022Article
- Epidemiology of Brain and Other CNS Tumors.Current neurology and neuroscience reports · 2021Review
- Association betweenCardiovascular diagnosis and therapy · 2021Article
- Multi-omic profiling of pituitary thyrotropic cells and progenitors.BMC biology · 2021Article
- Large Scale Molecular Studies of Pituitary Neuroendocrine Tumors: Novel Markers, Mechanisms and Translational Perspectives.Cancers · 2021Review
- Genome-wide association study across pediatric central nervous system tumors implicates shared predisposition and points to 1q25.2 (PAPPA2) and 11p12 (LRRC4C) as novel candidate susceptibility loci.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Novel Insights into Pituitary Tumorigenesis: Genetic and Epigenetic Mechanisms.Endocrine reviews · 2020Review
- Risk factors for childhood and adult primary brain tumors.Neuro-oncology · 2019Review
- Article
- Association of PTTG1 polymorphism rs1895320, rs2910200 and rs6882742 with non-functioning pituitary adenomas in Chinese Han population: a case-control study.Metabolic brain disease · 2019Article
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Authors and funding
47 authors at 4 institutions in 1 country.
Zhao Ye1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Zhiqiang LiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Yongfei Wang1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Ying Mao1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Ming Shen1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Qilin Zhang1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Shiqi Li1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Liangfu Zhou1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Xuefei Shou1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Jianhua Chen1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. [2] Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhijian SongBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Zengyi Ma1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Zhaoyun Zhang1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yiming Li1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Hongying Ye1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Chuanxin HuangShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tao WangDepartment of Neurosurgery, Shanghai 5th People's Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Wenqiang He1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Yichao Zhang1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Rong Xie1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Nidan Qiao1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Huijia Qiu1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Shan HuangDepartment of Neurosurgery, Shanghai 5th People's Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Meng WangBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Jiawei ShenBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Zujia WenBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Wenjin LiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Ke LiuBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Juan ZhouBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Lin WangBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Jue JiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Yin WangDepartment of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Hong ChenDepartment of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Haixia ChengDepartment of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Zhifeng Shi1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Yuqian Zhu1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Daoying GengDepartment of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Zhenwei YaoDepartment of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Weijun TangDepartment of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Bin Lu1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Li Pan1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Yi Zhang1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Weimin Bao1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Jinsong Wu1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Kang Zheng1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Yongyong Shi1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. [2] Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3] Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai, China. [4] Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, Shanghai, China. [5] Department of Psychiatry, The First Teaching Hospital of Xinjiang Medical University, Urumqi, China. [6] Shandong Provincial Key Laboratory of Metabolic Disease, the Affiliated Hospital of Qingdao University, Qingdao, China.
Yao Zhao1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
Shanghai Jiao Tong University · CNFudan University · CNHuashan Hospital · CNShanghai Medical College of Fudan University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pituitary adenoma is one of the most common intracranial neoplasms, and its genetic basis remains largely unknown. To identify genetic susceptibility loci for sporadic pituitary adenoma, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. We first analyzed genome-wide SNP data in 771 pituitary adenoma cases and 2,788 controls and then carried forward the promising variants for replication in another 2 independent sets (2,542 cases and 3,620 controls in total). We identified three new susceptibility loci below the genome-wide significance threshold (P < 5 × 10(-8)) in the combined analyses: 10p12.31 (rs2359536, P(meta) = 2.25 × 10(-10) and rs10828088, P(meta) = 6.27 × 10(-10)), 10q21.1 (rs10763170, P(meta) = 6.88 × 10(-10)) and 13q12.13 (rs17083838, P(meta) = 1.89 × 10(-8)). This study is the first GWAS to our knowledge on sporadic pituitary adenoma, and our results provide insight into the genetic basis of this disease.
Indexed as
Polymorphism, Single NucleotideAdenomaAdultCase-Control StudiesChromosomes, Human, Pair 10Chromosomes, Human, Pair 13FemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedPituitary NeoplasmsSequence Analysis, DNA
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