Evidence map›Paper›PMID 26029575›Full record

ArticleRespiratory medicine case reports2015

Facioscapulohumeral muscular dystrophy and respiratory failure; what about the diaphragm?

A Hazenberg, N van Alfen, N B M Voet, H A M Kerstjens, P J Wijkstra

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

A HazenbergUniversity of Groningen, University Medical Center Groningen, Department of Pulmonology and Tuberculosis, Department of Home Mechanical Ventilation, Groningen, The Netherlands ; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, The Netherlands.
N van AlfenDepartment of Neurology and Clinical Neurophysiology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
N B M VoetDepartment of Rehabilitation, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, Nijmegen, RMC Groot Klimmendaal, Arnhem, The Netherlands.
H A M KerstjensUniversity of Groningen, University Medical Center Groningen, Department of Pulmonology and Tuberculosis, Department of Home Mechanical Ventilation, Groningen, The Netherlands ; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, The Netherlands.
P J WijkstraUniversity of Groningen, University Medical Center Groningen, Department of Pulmonology and Tuberculosis, Department of Home Mechanical Ventilation, Groningen, The Netherlands ; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, The Netherlands.
University Medical Center Groningen · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe present a case of facioscapulohumeral muscular dystrophy (FSHD) with a diaphragm paralysis as the primary cause of ventilatory failure. FSHD is an autosomal dominant inherited disorder with a restricted pattern of weakness. Although respiratory weakness is a relatively unknown in FSHD, it is not uncommon.

methodsWe report on the clinical findings of a 68-year old male who presented with severe dyspnea while supine.

resultsSupplementing our clinical findings with laboratory, electrophysiological and radiological performances led to the diagnosis of diaphragm paralysis. Arterial blood gas in sitting position without supplemental oxygen showed a mild hypercapnia. His sleep improved after starting non-invasive ventilation and his daytime sleepiness disappeared. DISCUSSION: We conclude that in patients with FSHD who have symptoms of nocturnal hypoventilation, an adequate assessment of the diaphragm is recommended. This is of great importance as we know that nocturnal hypoventilation can be treated effectively by non-invasive ventilation.

Indexed as

Chronic respiratory failureDiaphragm paralysisDUX4, double homeoboxFacioscapulohumeral muscular dystrophyFSHD, facioscapulohumeral muscular dystrophyFVC, forced vital capacityHCO3, bicarbonatekPa, kilopascalNIPPV, non-invasive positive pressure ventilationNon invasive positive pressure ventilationpaCO2, partial pressure of arterial carbon dioxidepaO2, partial pressure of arterial oxygenpH, acidity levelPSG, polysomnographySleepSpO2, oxygen saturationtcpCO2, transcutaneous carbon dioxide

Identifiers

PMID26029575
PMCPMC4356051
OpenAlexW2009131864

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.