Evidence map›Paper›PMID 26029493›Full record

ReviewCurrent environmental health reports2015

Environmental Influences on Genomic Imprinting.

Maya Kappil, Luca Lambertini, Jia Chen

Open access · bronzeAbstract readReview
In one paragraph

Review in Current environmental health reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Retinoic Acid Upregulates METTL14 Expression and the mInternational journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Mother-child transmission of epigenetic information by tunable polymorphic imprinting.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maya KappilDepartment of Preventive Medicine, Icahn School of Medicine at Mount Sinai, Box 1057, 1 Gustave Levy Place, New York, NY 10029, USA.
Luca LambertiniDepartment of Preventive Medicine, Icahn School of Medicine at Mount Sinai, Box 1057, 1 Gustave Levy Place, New York, NY 10029, USA ; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Box 1057, 1 Gustave Levy Place, New York, NY 10029, USA.
Jia ChenDepartment of Preventive Medicine, Icahn School of Medicine at Mount Sinai, Box 1057, 1 Gustave Levy Place, New York, NY 10029, USA ; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, Box 1057, 1 Gustave Levy Place, New York, NY 10029, USA ; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, Box 1057, 1 Gustave Levy Place, New York, NY 10029, USA ; Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, Box 1057, 1 Gustave Levy Place, New York, NY 10029, USA.
Icahn School of Medicine at Mount Sinai · US

Funding

The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2014 to 2026
$21.3M
Research Training Program in Pediatric ExposomicsT32HD049311 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2007 to 2026
$7.4M
Environment, Imprinting, and NeurodevelopmentR01ES022223 · NIEHS · EMORY UNIVERSITY · PI CHEN, JIA, MARSIT, CARMEN JOSEPH · 2013 to 2017
$4.3M
NICHD NIH HHS R01 HD067611NICHD NIH HHS T32 HD049311NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES022223NIEHS NIH HHS R01ES022223-01A1
6 · The paper itself

Abstract

Genomic imprinting refers to the epigenetic mechanism that results in the mono-allelic expression of a subset of genes in a parent-of-origin manner. These haploid genes are highly active in the placenta and are functionally implicated in the appropriate development of the fetus. Furthermore, the epigenetic marks regulating imprinted expression patterns are established early in development. These characteristics make genomic imprinting a potentially useful biomarker for environmental insults, especially during the in utero or early development stages, and for health outcomes later in life. Herein, we critically review the current literature regarding environmental influences on imprinted genes and summarize findings that suggest that imprinted loci are sensitive to known teratogenic agents, such as alcohol and tobacco, as well as less established factors with the potential to manipulate the in utero environment, including assisted reproductive technology. Finally, we discuss the potential of genomic imprinting to serve as an environmental sensor during early development.

Indexed as

Genomic ImprintingDNA MethylationEnvironmental ExposureEpigenesis, GeneticFemaleFetal DevelopmentHumansPregnancyearly developmentenvironmental exposuresepigenetic regulationgenomic imprintingplacenta

Identifiers

PMID26029493
PMCPMC4443909
OpenAlexW2102408189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.