Evidence map›Paper›PMID 26029481›Full record

ArticleJournal of diabetes mellitus2013

Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy.

Dotun Ogunyemi, Jun Xu, Arnold M Mahesan, Steve Rad, Eric Kim, Jacqueline Yano, Carolyn Alexander, Jerome I Rotter, Y-D Ida Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes mellitus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Dotun OgunyemiDepartment of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, USA ; Department of Medical Education, David Geffen School of Medicine at UCLA, Los Angeles, USA.
Jun XuDepartment of Medical Genetics, Cedars-Sinai Medical Center, Los Angeles, USA.
Arnold M MahesanDepartment of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, USA.
Steve RadDepartment of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, USA.
Eric KimDepartment of Medical Genetics, Cedars-Sinai Medical Center, Los Angeles, USA.
Jacqueline YanoDepartment of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, USA.
Carolyn AlexanderDepartment of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, USA.
Jerome I RotterDepartment of Medical Education, David Geffen School of Medicine at UCLA, Los Angeles, USA.
Y-D Ida ChenDepartment of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, USA.
Cedars-Sinai Medical Center · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
NCATS NIH HHS UL1 TR000124NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

objectiveTo profile the differential gene expression of the KEGG Adipocytokine Signaling pathway in omental compared to subcutaneous tissue in normal pregnancy. STUDY

designSubjects included 14 nonobese, normal glucose tolerant, healthy pregnant women. Matched omental and subcutaneous tissue were obtained at elective cesarean delivery. Gene expression was evaluated using microarray and validated by RT-PCR. Differential gene expression was defined as ≥1.5 fold increase at p < 0.05.

resultsSix genes were significantly downregulated with two upregulated genes in omental tissue. Downregulation of Adiponectin and Insulin Receptor substrate, key genes mediating insulin sensitivity, were observed with borderline upregulation of GLUT-1. There were downregulations of CD36 and acyl-CoA Synthetase Long-chain Family Member 1which are genes involved in fatty acid uptake and activation. There was a novel expression of Carnitine palmitoyltransferase 1C.

conclusionDifferential gene expression of Adipocytokine Signaling Pathway in omental relative to subcutaneous adipose tissue in normal pregnancy suggests a pattern of insulin resistance, hyperlipidemia, and inflammation.

Indexed as

Adipocytokine PathwayAdipose TissueInsulin ResistancePregnancy

Identifiers

PMID26029481
PMCPMC4447103
OpenAlexW2040148846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.