ArticleFrontiers in microbiology2015
Comparative genomics reveals diversified CRISPR-Cas systems of globally distributed Microcystis aeruginosa, a freshwater bloom-forming cyanobacterium.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Acclimation temperature influences phage susceptibility in a toxin-producing strain ofMicrobiology spectrum · 2026Article
- A metagenomic snapshot of metabolic potentials in wintertime eutrophic sediments of Lake Taihu inferred from metagenome-assembled genomes.Frontiers in microbiology · 2026Article
- Characterization of Five CRISPR Systems inInternational journal of molecular sciences · 2025Article
- CyanoStrainChip: A Novel DNA Microarray Tool for High-Throughput Detection of Environmental Cyanobacteria at the Strain Level.Environmental science & technology · 2024Article
- Ecological Dynamics of Broad- and Narrow-Host-Range Viruses Infecting the Bloom-Forming Toxic Cyanobacterium Microcystis aeruginosa.Applied and environmental microbiology · 2023Article
- Analysis of Probiotic Bacteria Genomes: Comparison of CRISPR/Cas Systems and Spacer Acquisition Diversity.Indian journal of microbiology · 2022Article
- Article
- Identification and Characterization of the CRISPR/Cas System inFrontiers in microbiology · 2021Article
- Cell Death in Cyanobacteria: Current Understanding and Recommendations for a Consensus on Its Nomenclature.Frontiers in microbiology · 2021Review
- Genomic Characteristics of the Toxic Bloom-Forming CyanobacteriumJournal of genomics · 2020Article
- Cooccurrence of Broad- and Narrow-Host-Range Viruses Infecting the Bloom-Forming Toxic Cyanobacterium Microcystis aeruginosa.Applied and environmental microbiology · 2019Article
- Article
- Metatranscriptomics analysis of cyanobacterial aggregates during cyanobacterial bloom period in Lake Taihu, China.Environmental science and pollution research international · 2018Article
- Incomplete Selective Sweeps ofFrontiers in microbiology · 2018Article
- Comparative Genomics of the Baltic Sea Toxic CyanobacteriaFrontiers in microbiology · 2018Article
- Article
- Article
- Orthocaspase and toxin-antitoxin loci rubbing shoulders in the genome of Microcystis aeruginosa PCC 7806.Current genetics · 2016Review
- Metagenomic Analysis Reveals Symbiotic Relationship among Bacteria in Microcystis-Dominated Community.Frontiers in microbiology · 2016Article
- Next-generation sequencing (NGS) for assessment of microbial water quality: current progress, challenges, and future opportunities.Frontiers in microbiology · 2015Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Microcystis aeruginosa is one of the most common and dominant bloom-forming cyanobacteria in freshwater lakes around the world. Microcystis cells can produce toxic secondary metabolites, such as microcystins, which are harmful to human health. Two M. aeruginosa strains were isolated from two highly eutrophic lakes in China and their genomes were sequenced. Comparative genomic analysis was performed with the 12 other available M. aeruginosa genomes and closely related unicellular cyanobacterium. Each genome of M. aeruginosa containing at least one clustered regularly interspaced short palindromic repeat (CRISPR) locus and total 71 loci were identified, suggesting it is ubiquitous in M. aeruginosa genomes. In addition to the previously reported subtype I-D cas gene sets, three CAS subtypes I-A, III-A and III-B were identified and characterized in this study. Seven types of CRISPR direct repeat have close association with CAS subtype, confirming that different and specific secondary structures of CRISPR repeats are important for the recognition, binding and process of corresponding cas gene sets. Homology search of the CRISPR spacer sequences provides a history of not only resistance to bacteriophages and plasmids known to be associated with M. aeruginosa, but also the ability to target much more exogenous genetic material in the natural environment. These adaptive and heritable defense mechanisms play a vital role in keeping genomic stability and self-maintenance by restriction of horizontal gene transfer. Maintaining genomic stability and modulating genomic plasticity are both important evolutionary strategies for M. aeruginosa in adaptation and survival in various habitats.
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