ArticleFrontiers in neurology2015
Dynamic changes in DNA methylation in ischemic tolerance.
Article in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Identification of mBMC medical genomics · 2023Article
- Possible Involvement of DNA Methylation in TSC1 Gene Expression in Neuroprotection Induced by Hypoxic Preconditioning.Oxidative medicine and cellular longevity · 2022Article
- Histone Methyltransferases SUV39H1 and G9a and DNA Methyltransferase DNMT1 in Penumbra Neurons and Astrocytes after Photothrombotic Stroke.International journal of molecular sciences · 2021Article
- Post-Treatment with Amorfrutin B Evokes PPARγ-Mediated Neuroprotection against Hypoxia and Ischemia.Biomedicines · 2021Article
- Endogenous neuroprotective mechanism of ATP2B1 in transcriptional regulation of ischemic preconditioning.American journal of translational research · 2021Article
- Genetic Aspects of Inflammation and Immune Response in Stroke.International journal of molecular sciences · 2020Review
- Overexpression of miR-217-5p protects against oxygen-glucose deprivation/reperfusion-induced neuronal injury via inhibition of PTEN.Human cell · 2020Article
- Investigating the Relationship Between Neuronal Cell Death and Early DNA Methylation After Ischemic Injury.Frontiers in neuroscience · 2020Article
- Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning.Frontiers in genetics · 2020Review
- A molecular signature for delayed graft function.Aging cell · 2018Article
- Epigenetic regulation of inflammation in stroke.Therapeutic advances in neurological disorders · 2018Review
- Regulation of gene expression in ischemic preconditioning in the brain.Conditioning medicine · 2017Article
- Ischemia/Reperfusion.Comprehensive Physiology · 2016Review
- Epigenetic modulation of gene expression governs the brain's response to injury.Neuroscience letters · 2016Review
- Article
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Authors and funding
3 authors.
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Abstract
Epigenetic mediators of gene expression are hypothesized to regulate transcriptomic responses to preconditioning ischemia and ischemic tolerance. Here, we utilized a methyl-DNA enrichment protocol and sequencing (ChIP-seq) to identify patterns of DNA methylation in an established model of ischemic tolerance in neuronal cultures (oxygen and glucose deprivation: OGD). We observed an overall decrease in global DNA methylation at 4 h following preconditioning ischemia (30 min OGD), harmful ischemia (120 min OGD), and in ischemic tolerant neuronal cultures (30 min OGD, 24 h recovery, 120 min OGD). We detected a smaller cohort of hypermethylated regions following ischemic conditions, which were further analyzed revealing differential chromosomal localization of methylation, and a differential concentration of methylation on genomic regions. Together, these data show that the temporal profiles of DNA methylation with respect to chromatin hyper- and hypo-methylation following various ischemic conditions are highly dynamic, and may reveal novel targets for neuroprotection.
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