ReviewFrontiers in neurology2015
Human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology.
Review in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Chronotype and Peripheral Clock Genes: Association With Frailty and Insomnia in Mexican Older Adults.Aging medicine (Milton (N.S.W)) · 2026Article
- Loss of Schwann cell's normal rhythmic core clock gene expression and gain of rhythmic expression of oncogenic driver genes in malignant NF1-associated peripheral nerve sheath tumor.Molecular & cellular oncology · 2025Article
- Peripheral clocks and systemicFrontiers in endocrinology · 2025Review
- Coupling allows robust mammalian redox circadian rhythms despite heterogeneity and noise.Heliyon · 2024Article
- Human circadian rhythm studies: Practical guidelines for inclusion/exclusion criteria and protocol.Neurobiology of sleep and circadian rhythms · 2022Review
- Time-restricted feeding alters the efficiency of mammary tumor growth.Chronobiology international · 2022Article
- Defining circadian disruption in neurodegenerative disorders.The Journal of clinical investigation · 2021Review
- Circadian Effects of Drug Responses.Annual review of biomedical engineering · 2021Article
- Circadian Influences on Chemotherapy Efficacy in a Mouse Model of Brain Metastases of Breast Cancer.Frontiers in oncology · 2021Article
- Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-Cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases, and Immunoproteasomal Activity.International journal of molecular sciences · 2020Article
- In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The importance of determining circadian parameters in pharmacological studies.British journal of pharmacology · 2019Review
- Cellular circadian period length inversely correlates with HbADiabetologia · 2019Article
- Validation of molecular biomarkers for preoperative diagnostics of human papillary thyroid carcinoma in fine needle aspirates.Gland surgery · 2019Article
- Generation and Characterization of Induced Pluripotent Stem Cells from Mononuclear Cells in Schizophrenic Patients.Cell journal · 2019Article
- Circadian rhythms: a regulator of gastrointestinal health and dysfunction.Expert review of gastroenterology & hepatology · 2019Review
- Daylight Saving Time and Artificial Time Zones - A Battle Between Biological and Social Times.Frontiers in physiology · 2019Review
- Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle.eLife · 2018Article
- Sleep, chronotype, and sleep hygiene in children with attention-deficit/hyperactivity disorder, autism spectrum disorder, and controls.European child & adolescent psychiatry · 2018Article
- Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expression.Genes & development · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most light-sensitive organisms on earth have acquired an internal system of circadian clocks allowing the anticipation of light or darkness. In humans, the circadian system governs nearly all aspects of physiology and behavior. Circadian phenotypes, including chronotype, vary dramatically among individuals and over individual lifespan. Recent studies have revealed that the characteristics of human skin fibroblast clocks correlate with donor chronotype. Given the complexity of circadian phenotype assessment in humans, the opportunity to study oscillator properties by using cultured primary cells has the potential to uncover molecular details difficult to assess directly in humans. Since altered properties of the circadian oscillator have been associated with many diseases including metabolic disorders and cancer, clock characteristics assessed in additional primary cell types using similar technologies might represent an important tool for exploring the connection between chronotype and disease, and for diagnostic purposes. Here, we review implications of this approach for gathering insights into human circadian rhythms and their function in health and disease.
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