ArticleFrontiers in neuroscience2015
A hypothesis for the evolution of the upper layers of the neocortex through co-option of the olfactory cortex developmental program.
Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- The Criticality of Consciousness: Excitatory-Inhibitory Balance and Dual Memory Systems in Active Inference.Entropy (Basel, Switzerland) · 2025Article
- Single-cell genomics of the mouse olfactory cortex reveals contrasts with neocortex and ancestral signatures of cell type evolution.Nature neuroscience · 2025Article
- Adaptive consolidation of active inference: excitatory and inhibitory mechanisms for organizing feedforward and feedback memory systems in sleep.Cerebral cortex (New York, N.Y. : 1991) · 2025Review
- Cilia directionality reveals a slow reverse movement of principal neurons for positioning and lamina refinement in the cerebral cortex.Development (Cambridge, England) · 2025Article
- Cross-species single-cell transcriptomics reveals neuronal similarities and heterogeneity in amniote pallium.Zoological research · 2025Article
- Beyond the canonical niche: how astrocytes carried neurogenic potential into the brain parenchyma.Frontiers in cell and developmental biology · 2025Review
- Craniodental anatomy in Permian-Jurassic Cynodontia and Mammaliaformes (Synapsida, Therapsida) as a gateway to defining mammalian soft tissue and behavioural traits.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
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- Neurophysiological mechanisms of implicit and explicit memory in the process of consciousness.Journal of neurophysiology · 2022Review
- Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution.Science (New York, N.Y.) · 2022Article
- Article
- Lineage Relationships Between Subpallial Progenitors and Glial Cells in the Piriform Cortex.Frontiers in neuroscience · 2022Article
- Evolving Roles of Notch Signaling in Cortical Development.Frontiers in neuroscience · 2022Review
- Sequential pattern of sublayer formation in the paleocortex and neocortex.Medical molecular morphology · 2020Article
- Article
- Molecular and cellular evolution of corticogenesis in amniotes.Cellular and molecular life sciences : CMLS · 2020Review
- Beyond Axon Guidance: Roles of Slit-Robo Signaling in Neocortical Formation.Frontiers in cell and developmental biology · 2020Review
- Neuron Names: A Gene- and Property-Based Name Format, With Special Reference to Cortical Neurons.Frontiers in neuroanatomy · 2019Article
- Non-Newly Generated, "Immature" Neurons in the Sheep Brain Are Not Restricted to Cerebral Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neocortical Lamination: Insights from Neuron Types and Evolutionary Precursors.Frontiers in neuroanatomy · 2017Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The neocortex is unique to mammals and its evolutionary origin is still highly debated. The neocortex is generated by the dorsal pallium ventricular zone, a germinative domain that in reptiles give rise to the dorsal cortex. Whether this latter allocortical structure contains homologs of all neocortical cell types it is unclear. Recently we described a population of DCX+/Tbr1+ cells that is specifically associated with the layer II of higher order areas of both the neocortex and of the more evolutionary conserved piriform cortex. In a reptile similar cells are present in the layer II of the olfactory cortex and the DVR but not in the dorsal cortex. These data are consistent with the proposal that the reptilian dorsal cortex is homologous only to the deep layers of the neocortex while the upper layers are a mammalian innovation. Based on our observations we extended these ideas by hypothesizing that this innovation was obtained by co-opting a lateral and/or ventral pallium developmental program. Interestingly, an analysis in the Allen brain atlas revealed a striking similarity in gene expression between neocortical layers II/III and piriform cortex. We thus propose a model in which the early neocortical column originated by the superposition of the lateral olfactory and dorsal cortex. This model is consistent with the fossil record and may account not only for the topological position of the neocortex, but also for its basic cytoarchitectural and hodological features. This idea is also consistent with previous hypotheses that the peri-allocortex represents the more ancient neocortical part. The great advances in deciphering the molecular logic of the amniote pallium developmental programs will hopefully enable to directly test our hypotheses in the next future.
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