Evidence map›Paper›PMID 26028918›Full record

ArticleJournal of Korean medical science2015

Comparison of Arbekacin and Vancomycin in Treatment of Chronic Suppurative Otitis Media by Methicillin Resistant Staphylococcus aureus.

Ji-Hee Hwang, Ju-Hyung Lee, Jeong-Hwan Hwang, Kyung Min Chung, Eun-Jung Lee, Yong-Joo Yoon, Mi-Kyoung Moon, Ju-Sin Kim, Kyoung-Suk Won, Chang-Seop Lee

Open access · goldAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 7 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 7 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Topical antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Systemic antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Topical antibiotics with steroids for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025
    Pooled it
  4. Topical versus systemic antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2021
    Pooled it
  5. Systemic antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2021
    Pooled it
  6. Topical antibiotics with steroids for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2020
    Pooled it
  7. Topical antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2020
    Pooled it
  8. Trial
  9. Article
  10. Article
  11. Clinical Usefulness of Arbekacin.Infection & chemotherapy · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ji-Hee HwangDepartment of Pharmacy, Chonbuk National University Hospital, Jeonju, Korea.
Ju-Hyung LeeDepartment of Preventive Medicine, Chonbuk National University Medical School, Jeonju, Korea. ; Research Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Jeonju, Korea.
Jeong-Hwan HwangDepartment of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
Kyung Min ChungDepartment of Microbiology & Immunology, Chonbuk National University Medical School, Jeonju, Korea.
Eun-Jung LeeDepartment of Otolaryngology-Head and Neck Surgery, Chonbuk National University Medical School, Jeonju, Korea.
Yong-Joo YoonResearch Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Jeonju, Korea. ; Department of Otolaryngology-Head and Neck Surgery, Chonbuk National University Medical School, Jeonju, Korea.
Mi-Kyoung MoonDepartment of Pharmacy, Chonbuk National University Hospital, Jeonju, Korea.
Ju-Sin KimDepartment of Pharmacy, Chonbuk National University Hospital, Jeonju, Korea.
Kyoung-Suk WonDepartment of Pharmacy, Chonbuk National University Hospital, Jeonju, Korea.
Chang-Seop LeeDepartment of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea. ; Research Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Jeonju, Korea.ORCID 0000-0002-2897-2202
Jeonbuk National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of ear infections. We attempted to evaluate the clinical usefulness of arbekacin in treating chronic suppurative otitis media (CSOM) by comparing its clinical efficacy and toxicity with those of vancomycin. Efficacy was classified according to bacterial elimination or bacteriologic failure and improved or failed clinical efficacy response. Ninety-five subjects were diagnosed with CSOM caused by MRSA. Twenty of these subjects were treated with arbekacin, and 36 with vancomycin. The bacteriological efficacy (bacterial elimination, arbekacin vs. vancomycin: 85.0% vs. 97.2%) and improved clinical efficacy (arbekacin vs. vancomycin; 90.0% vs. 97.2%) were not different between the two groups. However, the rate of complications was higher in the vancomycin group (33.3%) than in the arbekacin group (5.0%) (P=0.020). In addition, a total of 12 adverse reactions were observed in the vancomycin group; two for hepatotoxicity, one for nephrotoxicity, eight for leukopenia, two for skin rash, and one for drug fever. It is suggested that arbekacin be a good alternative drug to vancomycin in treatment of CSOM caused by MRSA.

Indexed as

AdultAgedAnti-Bacterial AgentsChronic DiseaseDibekacinFemaleHumansMaleMethicillin-Resistant Staphylococcus aureusMiddle AgedOtitis Media, SuppurativeStaphylococcal InfectionsTreatment OutcomeVancomycinYoung AdultAnti-Bacterial AgentsarbekacinDibekacinVancomycinArbekacinMethicillin-resistant Staphylococcus aureusOtitis MediaVancomycin

Identifiers

PMID26028918
PMCPMC4444466
OpenAlexW2147852807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.